(Q42743187)

English

Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells

scientific article published on 16 November 2009

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scholarly article

1 reference

Europe PubMed Central

6 November 2017

Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells (English)

1 reference

Europe PubMed Central

6 November 2017

object named as

Uri Hershberg

4

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author name string

Shannon M Anderson

1

1 reference

Europe PubMed Central

6 November 2017

Ashraf Khalil

2

1 reference

Europe PubMed Central

6 November 2017

Mohamed Uduman

3

1 reference

Europe PubMed Central

6 November 2017

Yoram Louzoun

5

1 reference

Europe PubMed Central

6 November 2017

Ann M Haberman

6

1 reference

Europe PubMed Central

6 November 2017

Steven H Kleinstein

7

1 reference

Europe PubMed Central

6 November 2017

Mark J Shlomchik

8

1 reference

Europe PubMed Central

6 November 2017

language of work or name

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publication date

16 November 2009

1 reference

Europe PubMed Central

6 November 2017

Journal of Immunology

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Europe PubMed Central

6 November 2017

183

1 reference

Europe PubMed Central

6 November 2017

11

1 reference

Europe PubMed Central

6 November 2017

7314-7325

1 reference

Europe PubMed Central

6 November 2017

A role for DRAK2 in the germinal center reaction and the antibody response

1 reference

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Germinal-center organization and cellular dynamics

1 reference

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27 May 2018

In vivo imaging of germinal centres reveals a dynamic open structure

1 reference

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Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor.

1 reference

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Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation

1 reference

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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

1 reference

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Follicular B helper T cells in antibody responses and autoimmunity.

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Bam32 Links the B Cell Receptor to ERK and JNK and Mediates B Cell Proliferation but Not Survival

1 reference

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Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases

1 reference

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BAFF: a fundamental survival factor for B cells.

1 reference

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Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis

1 reference

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27 May 2018

Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced

1 reference

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27 May 2018

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

1 reference

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Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

1 reference

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TCS: a computer program to estimate gene genealogies

1 reference

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27 May 2018

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

1 reference

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27 May 2018

Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells

1 reference

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

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27 May 2018

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

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27 May 2018

The dynamic structure of the germinal center.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106706

27 May 2018

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106706

27 May 2018

Clone: a Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selection

1 reference

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27 May 2018

T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

1 reference

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27 May 2018

The germinal center: a crucible for lymphocyte selection

1 reference

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27 May 2018

Tracing the development of single memory-lineage B cells in a highly defined immune response

1 reference

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27 May 2018

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

1 reference

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27 May 2018

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1 reference

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27 May 2018

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106706

27 May 2018

Germinal centers

1 reference

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27 May 2018

Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation

1 reference

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Modeling and optimization of populations subject to time-dependent mutation

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The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity

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gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory

1 reference

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27 May 2018

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

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27 May 2018

Somatic evolution of variable region structures during an immune response

1 reference

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Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

1 reference

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Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

1 reference

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Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1 reference

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Germ-line affinity and germ-line variable-region genes in the B cell response.

1 reference

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Follicular dendritic cells as accessory cells

1 reference

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V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.

1 reference

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Maturation of the immune response in germinal centers

1 reference

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Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.

1 reference

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16 August 2018

Imaging of germinal center selection events during affinity maturation

1 reference

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Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35.

1 reference

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CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.

1 reference

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B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers

1 reference

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Interplay between cell division and cell death during TCR triggering.

1 reference

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Analysis of mutational lineage trees from sites of primary and secondary Ig gene diversification in rabbits and chickens.

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Intracellular determination of activated caspases (IDAC) by flow cytometry using a pancaspase inhibitor labeled with FITC

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A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.

1 reference

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16 August 2018

Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens.

1 reference

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Quantification of cell turnover kinetics using 5-bromo-2'-deoxyuridine.

1 reference

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16 August 2018

Junctional amino acids determine the maturation pathway of an antibody.

1 reference

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Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice

1 reference

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16 August 2018

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.

1 reference

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16 August 2018

Improved methods for detecting selection by mutation analysis of Ig V region sequences

1 reference

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1 December 2018

In vivo imaging studies shed light on germinal-centre development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106706

1 December 2018

T cell division and death are segregated by mutation of TCRbeta chain constant domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germinal centers still hold secrets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of antigen-driven selection in germinal centres

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen and helper T lymphocytes activate B lymphocytes by distinct signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting the in situ behavior of a memory B cell clone during primary and secondary immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-Linking Surface Ig Delays CD40 Ligand- and IL-4-Induced B Cell Ig Class Switching and Reveals Evidence for Independent Regulation of B Cell Proliferation and Differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of BCR affinity in T cell dependent antibody responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-7-regulated homeostatic maintenance of recent thymic emigrants in association with caspase-mediated cell proliferation and apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19917681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.0902452

1 reference

Europe PubMed Central

6 November 2017

1 reference

Europe PubMed Central

6 November 2017

1 reference

Europe PubMed Central

6 November 2017

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