(Q42744337)

6 November 2017

title

Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1. (English)

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Charlie Chandsawangbhuwana

6 November 2017

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ChEBI release 2020-05-28

Michael E Baker

8

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4

object named as

Charlie Chandsawangbhuwana

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6 November 2017

Alex Odermatt

1

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6 November 2017

Thierry Da Cunha

2

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6 November 2017

Carlos A Penno

3

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6 November 2017

Christian Reichert

5

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6 November 2017

Armin Wolf

6

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6 November 2017

Min Dong

7

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6 November 2017

language of work or name

English

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publication date

1 June 2011

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6 November 2017

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6 November 2017

volume

436

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6 November 2017

issue

3

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6 November 2017

page(s)

621-629

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Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics

6 November 2017

cites work

1 reference

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Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis

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Bile salt biotransformations by human intestinal bacteria

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Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives by Bacteroides intestinalis AM-1 isolated from human feces

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Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid

21 January 2018

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Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1.

21 January 2018

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Readjusting the glucocorticoid balance: an opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity?

21 January 2018

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Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease

21 January 2018

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11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents

21 January 2018

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The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations

21 January 2018

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Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum: possible implication in the metabolic syndrome

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Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines.

21 January 2018

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The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening

21 January 2018

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Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes

21 January 2018

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Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli

21 January 2018

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Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity

21 January 2018

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Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism

21 January 2018

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Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme

21 January 2018

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Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids

21 January 2018

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Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat

21 January 2018

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11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase

21 January 2018

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Lumenal orientation and post-translational modifications of the liver microsomal 11 beta-hydroxysteroid dehydrogenase

21 January 2018

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21 January 2018

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Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor

21 January 2018

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Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase

21 January 2018

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Short-chain dehydrogenases/reductases (SDR)

21 January 2018

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Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family

21 January 2018

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Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes

21 January 2018

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Purification and characterization of hamster liver microsomal 7alpha-hydroxycholesterol dehydrogenase. Similarity to type I 11beta-hydroxysteroid dehydrogenase

21 January 2018

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7alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

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11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose

21 January 2018

1 reference

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Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

1 reference

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Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation

21 January 2018

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11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20110022

1 reference

6 November 2017

1 reference