(Q42798732)

7 November 2017

title

The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome (English)

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7 November 2017

1

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ORCID Public Data File 2021

7 November 2017

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Owen M Bradfield

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ORCID Public Data File 2021

author name string

O M Bradfield

2

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7 November 2017

M Tymms

3

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7 November 2017

S Zavarsek

4

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7 November 2017

T Hatzistavrou

5

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7 November 2017

I Kola

6

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7 November 2017

P J Hertzog

7

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7 November 2017

publication date

1 July 2003

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Biochimica et Biophysica Acta

7 November 2017

published in

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7 November 2017

volume

1628

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7 November 2017

issue

2

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7 November 2017

page(s)

105-110

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Down syndrome phenotypes: the consequences of chromosomal imbalance

7 November 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

The DNA sequence of human chromosome 21

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7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

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7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

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https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Developmental and aging changes in the expression of amyloid precursor protein in Down syndrome brains

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7 January 2021

Molecular mapping of Alzheimer-type dementia in Down's syndrome

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https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Differences in beta-amyloid (beta/A4) deposition in human patients with Down's syndrome and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Early amyloid-beta deposits show different immunoreactivity to the amino- and carboxy-terminal regions of beta-peptide in Alzheimer's disease and Down's syndrome brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Diffuse plaques in the cerebellum and corpus striatum in Down's syndrome contain amyloid beta protein (A beta) only in the form of A beta 42(43)

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

The pathological association between Down syndrome and Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Beta-amyloid, neuronal death and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Presenilin function in APP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Overlapping binding sites of two different transcription factors in the promoter of the human gene for the Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

USF binds to the APBα sequence in the promoter of the amyloid β-protein precursor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

The helix-loop-helix transcription factor USF interacts with the basal promoter of human amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Regulation of gene expression by transcription factors Ets-1 and Ets-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Alzheimer's disease. In search of gamma-secretase.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta2 leukocyte integrin) promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Sp1/Sp3 and PU.1 differentially regulate beta(5) integrin gene expression in macrophages and osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Mouse integrin alphav promoter is regulated by transcriptional factors Ets and Sp1 in melanoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

N-Acetyl-L-Cystein downregulates beta-amyloid precursor protein gene transcription in human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

pEF-BOS, a powerful mammalian expression vector

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

c-ets-2 protooncogene has mitogenic and oncogenic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2803%2900121-0

7 January 2021

10.1016/S0167-4781(03)00121-0

Identifiers

DOI

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7 November 2017

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