(Q42813699)

7 November 2017

title

PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression (English)

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7 November 2017

Tanya Nekrasova

1

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7 November 2017

Audrey Minden

series ordinal

2

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7 November 2017

publication date

1 July 2011

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Journal of Cellular Biochemistry

7 November 2017

published in

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7 November 2017

volume

112

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7 November 2017

issue

7

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7 November 2017

page(s)

1795-1806

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p21 in cancer: intricate networks and multiple activities

7 November 2017

cites work

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

21 January 2018

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A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF

21 January 2018

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p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export

21 January 2018

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Identification of a mouse p21Cdc42/Rac activated kinase

21 January 2018

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Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis

21 January 2018

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Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling

21 January 2018

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Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor

21 January 2018

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Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis

21 January 2018

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

21 January 2018

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Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

21 January 2018

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Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

21 January 2018

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Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

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N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

21 January 2018

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Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification

21 January 2018

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

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Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

21 January 2018

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Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton.

21 January 2018

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Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin

21 January 2018

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

21 January 2018

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MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein

21 January 2018

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Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4.

21 January 2018

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Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F.

21 January 2018

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p21-activated kinases: three more join the Pak.

21 January 2018

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Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase

21 January 2018

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New functional activities for the p21 family of CDK inhibitors

21 January 2018

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Cytoplasmic p21Cip1 Is Involved in Ras-induced Inhibition of the ROCK/LIMK/Cofilin Pathway

21 January 2018

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PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor

21 January 2018

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

21 January 2018

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The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

21 January 2018

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

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P21-activated kinase is required for mitotic progression and regulates Plk1.

21 January 2018

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Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

21 January 2018

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HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

21 January 2018

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Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

21 January 2018

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Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

21 January 2018

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An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

21 January 2018

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 January 2018

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Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain

21 January 2018

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Activated PAK4 regulates cell adhesion and anchorage-independent growth

21 January 2018

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PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

21 January 2018

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Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

21 January 2018

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PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

21 January 2018

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Structural framework for the protein kinase family

21 January 2018

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The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity.

21 January 2018

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Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation.

21 January 2018

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Spatial p21 expression profile in the mid-term mouse embryo.

21 January 2018

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

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Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6

21 January 2018

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Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts

21 January 2018

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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

21 January 2018

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Negative and positive regulation of gene expression by mouse histone deacetylase 1

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.23092

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7 November 2017

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