(Q42814656)

7 November 2017

title

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. (English)

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7 November 2017

author

Shigetsugu Hatakeyama

7

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7 November 2017

Hong Wu

1

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7 November 2017

Scott L Pomeroy

2

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7 November 2017

Manuel Ferreira

3

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7 November 2017

Natalia Teider

4

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7 November 2017

Juliana Mariani

5

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7 November 2017

Keiichi I Nakayama

6

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7 November 2017

Victor A Tron

8

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7 November 2017

Linda F Saltibus

9

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7 November 2017

Leo Spyracopoulos

10

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7 November 2017

Roger P Leng

11

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7 November 2017

language of work or name

English

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publication date

13 February 2011

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7 November 2017

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7 November 2017

volume

17

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7 November 2017

issue

3

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7 November 2017

page(s)

347-355

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https://scigraph.springernature.com/pub.10.1038/nm.2283

7 November 2017

exact match

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cites work

p53, the cellular gatekeeper for growth and division

1 reference

21 January 2018

Surfing the p53 network

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

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Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths

21 January 2018

1 reference

Recognition of the polyubiquitin proteolytic signal

21 January 2018

1 reference

21 January 2018

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

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Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

21 January 2018

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

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A proteolytic pathway that recognizes ubiquitin as a degradation signal

21 January 2018

1 reference

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

21 January 2018

1 reference

U box proteins as a new family of ubiquitin-protein ligases

21 January 2018

1 reference

Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p

21 January 2018

1 reference

How the cyclin became a cyclin: regulated proteolysis in the cell cycle

21 January 2018

1 reference

Molecular clearance of ataxin-3 is regulated by a mammalian E4

21 January 2018

1 reference

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis

21 January 2018

1 reference

UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination

21 January 2018

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Mammalian E4 is required for cardiac development and maintenance of the nervous system

21 January 2018

1 reference

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

Molecular basis of Pirh2-mediated p53 ubiquitylation

21 January 2018

1 reference

The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

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CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.

21 January 2018

1 reference

Yin Yang 1 is a negative regulator of p53.

21 January 2018

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

p53 Pathway dysfunction in primary childhood ependymomas

21 January 2018

1 reference

Medulloblastoma in childhood: new biological advances

21 January 2018

1 reference

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

21 January 2018

1 reference

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

21 January 2018

1 reference

12 December 2020

Cell-cycle arrest versus cell death in cancer therapy

1 reference

12 December 2020

p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma.

1 reference

12 December 2020

Infrequent p53 gene mutations in medulloblastomas.

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12 December 2020

Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens

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12 December 2020

p53 is frequently mutated in Burkitt's lymphoma cell lines

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12 December 2020

Identifiers

DOI

10.1038/NM.2283

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7 November 2017

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