(Q42828427)

English

Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth

scientific article published on July 1998

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth (English)

1 reference

Europe PubMed Central

8 November 2017

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5

object named as

LeRoith D

1 reference

Europe PubMed Central

8 November 2017

author name string

Blakesley VA

1

1 reference

Europe PubMed Central

8 November 2017

Koval AP

2

1 reference

Europe PubMed Central

8 November 2017

Stannard BS

3

1 reference

Europe PubMed Central

8 November 2017

Scrimgeour A

4

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Europe PubMed Central

8 November 2017

language of work or name

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publication date

1 July 1998

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Europe PubMed Central

8 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

8 November 2017

273

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Europe PubMed Central

8 November 2017

18411-18422

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Europe PubMed Central

8 November 2017

29

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Europe PubMed Central

8 November 2017

Molecular and cellular aspects of the insulin-like growth factor I receptor

1 reference

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21 January 2018

Role of insulin-like growth factors in embryonic and postnatal growth

1 reference

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21 January 2018

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

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21 January 2018

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

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21 January 2018

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

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21 January 2018

Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I

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21 January 2018

Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.

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21 January 2018

Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function

1 reference

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21 January 2018

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor

1 reference

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21 January 2018

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant

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21 January 2018

Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor

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21 January 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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21 January 2018

Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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21 January 2018

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

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21 January 2018

Insulin-like growth factors regulate neuronal differentiation and survival.

1 reference

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21 January 2018

Cytoskeleton--plasma membrane interactions

1 reference

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21 January 2018

The molecular architecture of focal adhesions

1 reference

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21 January 2018

Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation

1 reference

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21 January 2018

Structures linking microfilament bundles to the membrane at focal contacts

1 reference

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21 January 2018

Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton

1 reference

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21 January 2018

Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells.

1 reference

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21 January 2018

Vinculin-deficient PC12 cell lines extend unstable lamellipodia and filopodia and have a reduced rate of neurite outgrowth

1 reference

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21 January 2018

Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone

1 reference

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21 January 2018

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion

1 reference

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21 January 2018

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

1 reference

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21 January 2018

Insulin-like growth factor-1-mediated association of p85 phosphatidylinositol 3-kinase with pp 185: requirement of SH2 domains for in vivo interaction

1 reference

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21 January 2018

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

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21 January 2018

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

1 reference

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21 January 2018

Proteins regulating Ras and its relatives

1 reference

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21 January 2018

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

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21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

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21 January 2018

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

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21 January 2018

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

1 reference

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21 January 2018

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

1 reference

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21 January 2018

Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system

1 reference

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21 January 2018

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

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21 January 2018

The 3Rs of life: Ras, Raf and growth regulation

1 reference

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21 January 2018

Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

1 reference

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21 January 2018

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

1 reference

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21 January 2018

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.

1 reference

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21 January 2018

Interaction of p85 subunit of PI 3-kinase with insulin and IGF-1 receptors analysed by using the two-hybrid system

1 reference

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21 January 2018

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

1 reference

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21 January 2018

Insulin-like growth factor receptors

1 reference

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21 January 2018

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1 reference

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21 January 2018

Influence of fibroblast growth factor (bFGF) and insulin-like growth factor (IGF-I) on cytoskeletal and contractile structures and on atrial natriuretic factor (ANF) expression in adult rat ventricular cardiomyocytes in culture

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21 January 2018

Insulin-like growth factor I (IGF-I) induces unique effects in the cytoskeleton of cultured rat glomerular mesangial cells

1 reference

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21 January 2018

Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance

1 reference

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21 January 2018

Integrins and signal transduction pathways: the road taken

1 reference

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21 January 2018

Cell adhesion molecules and insulin-like growth factor-1 in vascular disease

1 reference

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21 January 2018

Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen

1 reference

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21 January 2018

Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells

1 reference

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21 January 2018

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

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21 January 2018

Identifiers

10.1074/JBC.273.29.18411

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

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