(Q42831977)

8 November 2017

title

SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway (English)

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8 November 2017

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Christina I Zito

1

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8 November 2017

Hui Qin

series ordinal

2

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8 November 2017

John Blenis

series ordinal

3

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8 November 2017

Anton M Bennett

series ordinal

4

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8 November 2017

language of work or name

English

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publication date

17 January 2007

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

282

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8 November 2017

issue

10

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8 November 2017

page(s)

6946-6953

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TOR signaling in growth and metabolism

8 November 2017

cites work

1 reference

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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Rheb binds and regulates the mTOR kinase

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TSC2 mediates cellular energy response to control cell growth and survival

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The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

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Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

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Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

21 January 2018

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SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway

21 January 2018

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A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

21 January 2018

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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

21 January 2018

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21 January 2018

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Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

21 January 2018

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608338200

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608338200

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

21 January 2018

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 January 2018

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Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

21 January 2018

1 reference

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Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608338200

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608338200

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608338200

21 January 2018

Identifiers

DOI

10.1074/JBC.M608338200

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8 November 2017

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