(Q42864670)

8 November 2017

A two-step chemical mechanism for ribosome-catalysed peptide bond formation (English)

1 reference

8 November 2017

David A Hiller

1

1 reference

8 November 2017

Vipender Singh

series ordinal

2

1 reference

8 November 2017

Minghong Zhong

series ordinal

3

1 reference

8 November 2017

Scott A Strobel

series ordinal

4

1 reference

8 November 2017

language of work or name

English

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publication date

17 July 2011

1 reference

8 November 2017

1 reference

8 November 2017

476

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8 November 2017

7359

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8 November 2017

236-239

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https://scigraph.springernature.com/pub.10.1038/nature10248

8 November 2017

0 references

cites work

The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

The transition state for peptide bond formation reveals the ribosome as a water trap

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Structure of the 70S ribosome complexed with mRNA and tRNA

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

The ribosome as an entropy trap

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Mononucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2'-OH to activity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

The structural basis of ribosome activity in peptide bond synthesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

RNA-catalysed nucleotide synthesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Isotope effects: determination of enzyme transition state structure

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

The mechanism of the aminolysis of acetate esters.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Catalytic role of vicinal OH in ester aminolysis: proton shuttle versus hydrogen bond stabilization

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

THE REACTIVITY OF NUCLEOPHILIC REAGENTS WITH FUROYL-CHYMOTRYPSIN

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154986

An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE10248

Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide

21 January 2018

1 reference

12 December 2020

Transition state charge distribution in reactions of an acetyltyrosylchymotrypsin intermediate

1 reference

12 December 2020

Synthesis of the ribosomal P-site substrate CCA-pcb

1 reference

12 December 2020

Peptide bond formation does not involve acid-base catalysis by ribosomal residues

1 reference

12 December 2020

H-Bonding in Alcohols Is Reflected in the Cα−H Bond Strength: Variation of C−D Vibrational Frequency and Fractionation Factor

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE10248

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE10248

1 reference

Dimensions Publication ID

8 November 2017

0 references

1 reference

8 November 2017

1 reference