(Q42876716)

English

KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation

scientific article published on November 1, 2010

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Europe PubMed Central

PubMed publication ID

9 November 2017

KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation (English)

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Europe PubMed Central

PubMed publication ID

9 November 2017

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phosphorylation

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Jwu-Lai Yeh

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20 July 2024

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Chee-Yin Chai

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20 July 2024

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Hui-Hsuan Chung

1

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9 November 2017

Zen-Kong Dai

2

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9 November 2017

Bin-Nan Wu

3

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9 November 2017

Koung-Shing Chu

6

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9 November 2017

Chung-Pin Liu

7

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9 November 2017

Ing-Jun Chen

8

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Europe PubMed Central

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9 November 2017

language of work or name

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National Center for Biotechnology Information

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20870034

20 July 2024

publication date

1 October 2010

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9 November 2017

November 2010

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20 July 2024

full work available at URL

https://api.elsevier.com/content/article/PII:S153718911000131X?httpAccept=text/xml

1 reference

10.1016/J.VPH.2010.09.003

https://api.crossref.org/works/10.1016/J.VPH.2010.09.003

20 July 2024

https://api.elsevier.com/content/article/PII:S153718911000131X?httpAccept=text/plain

1 reference

10.1016/J.VPH.2010.09.003

https://api.crossref.org/works/10.1016/J.VPH.2010.09.003

20 July 2024

Vascular Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

9 November 2017

53

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PubMed publication ID

9 November 2017

5-6

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Europe PubMed Central

PubMed publication ID

9 November 2017

239-249

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Europe PubMed Central

PubMed publication ID

9 November 2017

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

1 reference

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PDGF signaling in pulmonary arterial hypertension

1 reference

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Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation

1 reference

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Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.

1 reference

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Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice

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Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine(2B) receptors in mice

1 reference

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The power issue: determination of KB or Ki from IC50. A closer look at the Cheng-Prusoff equation, the Schild plot and related power equations.

1 reference

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The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase

1 reference

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Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro

1 reference

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Pulmonary hypertension: therapeutic targets within the serotonin system.

1 reference

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Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

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Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin

1 reference

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7 January 2021

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

1 reference

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7 January 2021

Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors

1 reference

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7 January 2021

Endothelium-dependent relaxation of porcine pulmonary arteries via 5-HT1C-like receptors.

1 reference

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7 January 2021

Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation

1 reference

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7 January 2021

Translocation of rhoA associated with Ca2+ sensitization of smooth muscle

1 reference

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7 January 2021

Abnormal sarcoplasmic reticulum Ca2+-sequestering properties in skeletal muscle in chronic obstructive pulmonary disease.

1 reference

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Modulation of ion channels in pulmonary arterial hypertension.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

7 January 2021

Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

7 January 2021

Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.

1 reference

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7 January 2021

RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling

1 reference

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7 January 2021

Fluvastatin reduces pulmonary vein spontaneous activity through nitric oxide pathway.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

7 January 2021

Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

7 January 2021

High Plasma Serotonin Levels in Primary Pulmonary Hypertension

1 reference

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Alterations of Ca2+ mobilizing properties in migrating endothelial cells

1 reference

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Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin

1 reference

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Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture

1 reference

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7 January 2021

Regulation of serotonin-induced DNA synthesis of bovine pulmonary artery smooth muscle cells

1 reference

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H(2)O(2) signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

7 January 2021

Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells

1 reference

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Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2010.09.003

7 January 2021

Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin

1 reference

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Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?

1 reference

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5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

1 reference

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Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.

1 reference

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Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

1 reference

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Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension

1 reference

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Hypoxic pulmonary vasoconstriction: role of ion channels

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Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist

1 reference

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Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways

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Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration

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Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries

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Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels

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Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

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Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension.

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Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle

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Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil

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Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors

1 reference

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10.1016/J.VPH.2010.09.003

1 reference

Europe PubMed Central

PubMed publication ID

9 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 November 2017

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