(Q42917885)

11 November 2017

title

Aminoglycosides redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases (English)

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11 November 2017

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Varvara Pokrovskaya

1

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11 November 2017

Igor Nudelman

series ordinal

2

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11 November 2017

Jeyakumar Kandasamy

series ordinal

3

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11 November 2017

Timor Baasov

series ordinal

4

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11 November 2017

language of work or name

English

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publication date

1 January 2010

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11 November 2017

published in

Methods in Enzymology

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11 November 2017

volume

478

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11 November 2017

page(s)

437-462

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Structural basis for selectivity and toxicity of ribosomal antibiotics

11 November 2017

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Aminoglycoside antibiotics

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Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA

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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

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A new class of branched aminoglycosides: pseudo-pentasaccharide derivatives of neomycin B

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Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

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Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives

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Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa

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7 January 2021

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases

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7 January 2021

Aminoglycoside antibiotics: old drugs and new therapeutic approaches

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7 January 2021

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

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7 January 2021

Mitochondrial deafness alleles confer misreading of the genetic code

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7 January 2021

Sequence specificity of aminoglycoside-induced stop condon readthrough: potential implications for treatment of Duchenne muscular dystrophy

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7 January 2021

Readthrough of dystrophin stop codon mutations induced by aminoglycosides

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7 January 2021

Characterization of a bifunctional aminoglycoside-modifying enzyme with novel substrate specificity and its gene from a clinical isolate of methicillin-resistant Staphylococcus aureus with high arbekacin resistance

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7 January 2021

Molecular understanding of aminoglycoside action and resistance

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7 January 2021

Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

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7 January 2021

Aminoglycosides as potential pharmacogenetic agents in the treatment of Hailey-Hailey disease

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7 January 2021

Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications.

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7 January 2021

Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites

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7 January 2021

Fidelity of protein synthesis with chicken embryo mitochondrial and cytoplasmic ribosomes

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7 January 2021

Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics

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7 January 2021

Chemoenzymatic acylation of aminoglycoside antibiotics

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Novel heterodimer antibiotics: a review of recent patent literature

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7 January 2021

Molecular insights into aminoglycoside action and resistance

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7 January 2021

Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

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7 January 2021

Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones

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7 January 2021

Interaction of antibiotics with functional sites in 16S ribosomal RNA

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7 January 2021

Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity

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7 January 2021

Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations

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7 January 2021

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations

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7 January 2021

Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations

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7 January 2021

Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ

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7 January 2021

Structural insights into translational fidelity

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7 January 2021

Chemical decay of an antibiotic inverts selection for resistance.

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7 January 2021

Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics

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7 January 2021

In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Anthrax lethal factor inhibition

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7 January 2021

New insights into aminoglycoside antibiotics and derivatives.

1 reference

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7 January 2021

Paromomycin in the treatment of leishmaniasis

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7 January 2021

Versatility of aminoglycosides and prospects for their future

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7 January 2021

Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2978021-6

7 January 2021

Drug interactions and the evolution of antibiotic resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2978021-6

7 January 2021

The bifunctional enzymes of antibiotic resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2978021-6

7 January 2021

Modifications of aminoglycoside antibiotics targeting RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2978021-6

7 January 2021

Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2978021-6

7 January 2021

10.1016/S0076-6879(10)78021-6

Identifiers

DOI

1 reference

11 November 2017

1 reference