(Q42999680)

12 November 2017

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Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease (English)

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12 November 2017

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dengue NS2B-NS3 protease

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based on heuristic

inferred from abstract

4

Gottfried Otting

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12 November 2017

Laura de la Cruz

1

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12 November 2017

Wan-Na Chen

series ordinal

2

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12 November 2017

Bim Graham

series ordinal

3

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12 November 2017

language of work or name

English

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publication date

12 February 2014

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12 November 2017

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12 November 2017

volume

281

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12 November 2017

issue

6

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12 November 2017

page(s)

1517-1533

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The global distribution and burden of dengue

12 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Research on dengue and dengue-like illness in East Asia and the Western Pacific during the First Half of the 20th century

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Dengue: a continuing global threat

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Serotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Cell-free transcription/translation from PCR-amplified DNA for high-throughput NMR studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Structure-based discovery of dengue virus protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Anthracene-based inhibitors of dengue virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Structure-guided fragment-based in silico drug design of dengue protease inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Tripeptide inhibitors of dengue and West Nile virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Activation of dengue protease autocleavage at the NS2B–NS3 junction by recombinant NS3 and GST–NS2B fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Primary structure effects on peptide group hydrogen exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Design, structure-based focusing and in silico screening of combinatorial library of peptidomimetic inhibitors of Dengue virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Designing cyclic peptide inhibitor of dengue virus NS3-NS2B protease by using molecular docking approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Design of new competitive dengue NS2B/NS3 protease inhibitors-a computational approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Characterization of 8-hydroxyquinoline derivatives containing aminobenzothiazole as inhibitors of dengue virus type 2 protease in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Discovery and SAR studies of methionine-proline anilides as dengue virus NS2B-NS3 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Practical protocols for production of very high yields of recombinant proteins using Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

The pRSET family of T7 promoter expression vectors for Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Interaction of the Escherichia coli replication terminator protein (Tus) with DNA: a model derived from DNA-binding studies of mutant proteins by surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

N-Labelled proteins by cell-free protein synthesis. Strategies for high-throughput NMR studies of proteins and protein-ligand complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Optimization of an Escherichia coli system for cell-free synthesis of selectively N-labelled proteins for rapid analysis by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enymes for selective 15N-labelling and production of perdeuterated proteins in H2O.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Accurate quantitation of water-amide proton exchange rates using the phase-modulated CLEAN chemical EXchange (CLEANEX-PM) approach with a Fast-HSQC (FHSQC) detection scheme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

DOTA-Amide Lanthanide Tag for Reliable Generation of Pseudocontact Shifts in Protein NMR Spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

Magnetic susceptibility in paramagnetic NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12729

21 January 2018

Identifiers

DOI

10.1111/FEBS.12729

1 reference

12 November 2017

1 reference