(Q43011644)

English

Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma

scientific article published in June 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Libero Santarpia

1

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Steven I. Sherman

object named as

Steven I Sherman

3

0 references

author name string

Jeffrey N Myers

2

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Francesco Trimarchi

4

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Gary L Clayman

5

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

Adel K El-Naggar

6

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

language of work or name

0 references

publication date

1 June 2010

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

116

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

2974-2983

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

The Role of the PAX8/PPARgamma Fusion Oncogene in Thyroid Cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

21 January 2018

RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific pattern of RAS oncogene mutations in follicular thyroid tumors

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection and molecular characterization of a novel BRAF activated domain mutation in follicular variant of papillary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

BRAF mutations are associated with some histological types of papillary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a novel complex BRAF mutation in a follicular variant papillary thyroid carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Thyroid carcinoma: molecular pathways and therapeutic targets

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

PPARgamma staining as a surrogate for PAX8/PPARgamma fusion oncogene expression in follicular neoplasms: clinicopathological correlation and histopathological diagnostic value

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Cowden Syndrome

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

AKT in thyroid tumorigenesis and progression

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of the PIK3CA gene in anaplastic thyroid cancer.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan).

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting RAS signalling pathways in cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular genetic study comparing follicular variant versus classic papillary thyroid carcinomas: association of N-ras mutation in codon 61 with follicular variant.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.25061

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CNCR.25061

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 November 2017

ResearchGate publication ID

0 references

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