(Q43039843)

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Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients.

scientific article published on 29 June 2007

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3 January 2020

Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients (English)

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3 January 2020

chronic hepatitis C

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Markus Cornberg

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Michael P Manns

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3 January 2020

Heiner Wedemeyer

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Heiner Wedemeyer

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Verena Schlaphoff

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Christoph S Klade

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Bernd Jilma

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Sandra B Jelovcan

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IC41 Study Group

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29 June 2007

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3 January 2020

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3 January 2020

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Vaccination of chimpanzees with plasmid DNA encoding the hepatitis C virus (HCV) envelope E2 protein modified the infection after challenge with homologous monoclonal HCV.

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A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C.

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Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2.

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Hepatitis C virus-derived lipopeptides differentially induce epitope-specific immune responses in vitro.

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Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

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Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection

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Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

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CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation.

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Lymphocyte homing and homeostasis

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation

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Faces and phases of human CD8 T-cell development.

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Understanding the generation and function of memory T cell subsets

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Functional subsets of memory T cells identified by CCR7 expression

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Immunity and immunological memory following smallpox vaccination

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Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens.

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Analysis of naïve and memory CD4 and CD8 T cell populations in breast cancer patients receiving a HER2/neu peptide (E75) and GM-CSF vaccine.

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Quiescent phenotype of tumor-specific CD8+ T cells following immunization

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Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccination

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Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells

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Human virus-specific CD8+ T cells: diversity specialists.

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

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CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

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Comparison between HIV- and CMV-specific T cell responses in long-term HIV infected donors

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Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers

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EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function.

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Analysis of successful immune responses in persons infected with hepatitis C virus

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Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization

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Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

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Induction of therapeutically relevant cytotoxic T lymphocytes in humans by percutaneous peptide immunization.

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Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites

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Duration of antiviral immunity after smallpox vaccination

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Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential

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Lineage relationship and protective immunity of memory CD8 T cell subsets

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Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

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Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells

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Identifiers

10.1016/J.VACCINE.2007.06.026

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17686555%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17686555%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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