(Q43045813)

English

Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.

scientific article published on 3 June 2010

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scholarly article

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4 February 2020

Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy (English)

1 reference

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4 February 2020

endoplasmic reticulum

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8

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4 February 2020

Christopher Redfern

7

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4 February 2020

Jane L Armstrong

9

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4 February 2020

10

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Penny E Lovat

1 reference

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4 February 2020

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author name string

Emma L Hiscutt

1

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4 February 2020

David S Hill

2

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4 February 2020

Shaun Martin

3

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4 February 2020

Ryan Kerr

4

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4 February 2020

Andrew Harbottle

5

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4 February 2020

Mark Birch-Machin

6

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4 February 2020

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3 June 2010

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4 February 2020

Journal of Investigative Dermatology

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4 February 2020

130

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4 February 2020

9

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4 February 2020

2250-2258

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4 February 2020

https://scigraph.springernature.com/pub.10.1038/jid.2010.146

0 references

Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours

1 reference

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Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system

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A system for stable expression of short interfering RNAs in mammalian cells

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A novel role for XIAP in copper homeostasis through regulation of MURR1

1 reference

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7 January 2021

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Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

1 reference

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Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57

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Mutations of the BRAF gene in human cancer

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Cutaneous melanoma susceptibility and progression genes

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Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer

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Immunohistochemical detection of XIAP in melanoma

1 reference

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7 January 2021

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Toward a molecular classification of melanoma.

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Guilty as charged: B-RAF is a human oncogene

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Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibited

1 reference

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Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma

1 reference

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The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

1 reference

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7 January 2021

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Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

1 reference

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Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.

1 reference

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7 January 2021

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Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma.

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Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression

1 reference

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The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro

1 reference

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7 January 2021

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Targeting XIAP for the treatment of malignancy

1 reference

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Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

1 reference

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Up-regulation of p21WAF1 by phorbol ester and calcium in human keratinocytes through a protein kinase C-dependent pathway

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NF-kappaB activation in melanoma

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Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.

1 reference

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The inhibitor of apoptosis proteins as therapeutic targets in cancer

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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

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