(Q43099242)

English

Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.

scientific article published in April 2010

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Caenorhabditis elegans

0 references

prion protein family

0 references

Jean-Michel Peyrin

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Jean-Michel Peyrin

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Nicolas Bizat

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Stephane Haïk

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Véronique Cochois

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Patrick Beaudry

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Jean-Louis Laplanche

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

language of work or name

0 references

publication date

1 April 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

30

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

15

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

5394-5403

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6632766/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Prominent psychiatric features and early onset in an inherited prion disease with a new insertional mutation in the prion protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction through prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant prion proteins are partially retained in the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fundamentals of prion biology and diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA cloning of a novel heterogeneous nuclear ribonucleoprotein gene homologue in Caenorhabditis elegans using hamster prion protein cDNA as a hybridization probe

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein glycosylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of sporadic Creutzfeldt-Jakob disease revisited.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular prion protein signaling in serotonergic neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol stimulates AMP kinase activity in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cellular prion protein (PrP(C)): its physiological function and role in disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medicine. The yin-yang of sirtuins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion strain- and species-dependent effects of antiprion molecules in primary neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of prion pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology of the prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prion's elusive reason for being

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulating factors of PrP glycosylation in Creutzfeldt-Jakob disease--implications for the dissemination and the diagnosis of human prion strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant Creutzfeldt-Jakob disease in France and the United Kingdom: Evidence for the same agent strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion neurotoxicity: insights from prion protein mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical effects of SIRT1 activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unc-86 gene product couples cell lineage and cell identity in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics of Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characteristics of the major scrapie prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protease-resistant protein is a structural component of the scrapie prion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Mutant Prion Protein Displays an Aberrant Membrane Association When Expressed in Cultured Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Etiology and pathogenesis of prion diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human prion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular functions regulated by Src family kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20392961

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5831-09.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20392961%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q43099242&oldid=1660010184"