(Q43116255)

14 November 2017

title

Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation (English)

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14 November 2017

Nina Clementi

1

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14 November 2017

Anna Chirkova

2

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14 November 2017

Barbara Puffer

3

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14 November 2017

Ronald Micura

4

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14 November 2017

Norbert Polacek

5

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14 November 2017

publication date

28 March 2010

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14 November 2017

published in

Nature Chemical Biology

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14 November 2017

volume

6

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14 November 2017

issue

5

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14 November 2017

page(s)

344-351

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https://scigraph.springernature.com/pub.10.1038/nchembio.341

14 November 2017

exact match

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cites work

Ribosomal catalysis: the evolution of mechanistic concepts for peptide bond formation and peptidyl-tRNA hydrolysis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.341

Relationship between elongation factor 1- and elongation factor 2-dependent guanosine triphosphatase activities of ribosomes. Inhibition of both activities by ricin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.341

The mode of action of Shiga toxin on peptide elongation of eukaryotic protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.341

Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.341

Regulation of GTPases in the bacterial translation machinery

21 January 2018

1 reference

12 December 2020

Crystal structure of an RNA aptamer bound to thrombin

1 reference

12 December 2020

Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.

1 reference

12 December 2020

Interactions of translational factor EF-G with the bacterial ribosome before and after mRNA translocation

1 reference

12 December 2020

Mutational studies on the alpha-sarcin loop of Escherichia coli 23S ribosomal RNA.

1 reference

12 December 2020

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

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12 December 2020

EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition.

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12 December 2020

GTPase activation of elongation factors Tu and G on the ribosome

1 reference

12 December 2020

Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome

1 reference

12 December 2020

The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State

1 reference

12 December 2020

The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid.

1 reference

12 December 2020

GTPase activation of elongation factor EF-Tu by the ribosome during decoding

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12 December 2020

Control of phosphate release from elongation factor G by ribosomal protein L7/12.

1 reference

12 December 2020

A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions.

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12 December 2020

The location and the significance of a cross-link between the sarcin/ricin domain of ribosomal RNA and the elongation factor-G.

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12 December 2020

The sarcin-ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit

1 reference

12 December 2020

Efficient Ribosomal Peptidyl Transfer Critically Relies on the Presence of the Ribose 2‘-OH at A2451 of 23S rRNA

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12 December 2020

Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

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12 December 2020

An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination.

1 reference

12 December 2020

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

1 reference

12 December 2020

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451

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12 December 2020

The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form

1 reference

12 December 2020

Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM.

1 reference

12 December 2020

On the Mechanism of Protein-Synthesis Inhibition by Abrin and Ricin. Inhibition of the GTP-Hydrolysis Site on the 60-S Ribosomal Subunit

1 reference

12 December 2020

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1 reference

12 December 2020

A single base mutation at position 2661 in E. coli 23S ribosomal RNA affects the binding of ternary complex to the ribosome.

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12 December 2020

Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs

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12 December 2020

The identification of the determinants of the cyclic, sequential binding of elongation factors tu and g to the ribosome

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12 December 2020

Affinity Purification of Ribosomes with a Lethal G2655C Mutation in 23 S rRNA That Affects the Translocation

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12 December 2020

The ribosome-in-pieces: binding of elongation factor EF-G to oligoribonucleotides that mimic the sarcin/ricin and thiostrepton domains of 23S ribosomal RNA.

1 reference

12 December 2020

Reconstitution of functionally active Thermus aquaticus large ribosomal subunits with in vitro-transcribed rRNA.

1 reference

12 December 2020

The mechanism of the protein-synthesis elongation cycle in eukaryotes. Effect of ricin on the ribosomal interaction with elongation factors

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12 December 2020

tRNA selection and kinetic proofreading in translation

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12 December 2020

The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis.

1 reference

12 December 2020

New features of the ribosome and ribosomal inhibitors: non-enzymatic recycling, misreading and back-translocation

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12 December 2020

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

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12 December 2020

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

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12 December 2020

Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation

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12 December 2020

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

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12 December 2020

The phenotype of mutations of G2655 in the sarcin/ricin domain of 23 S ribosomal RNA.

1 reference

12 December 2020

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

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12 December 2020

The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome

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12 December 2020

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.341

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14 November 2017

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