(Q43120924)

14 November 2017

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease (English)

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14 November 2017

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Grace Schenatto Pereira

7

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14 November 2017

9

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14 November 2017

J G Doria

1

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14 November 2017

F R Silva

2

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14 November 2017

J M de Souza

3

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14 November 2017

L B Vieira

4

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14 November 2017

T G Carvalho

5

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14 November 2017

H J Reis

6

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14 November 2017

T Dobransky

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14 November 2017

language of work or name

English

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publication date

1 June 2013

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British Journal of Pharmacology

14 November 2017

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14 November 2017

169

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14 November 2017

4

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14 November 2017

909-921

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describes a project that uses

14 November 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3687670/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator

25 May 2018

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Huntington's disease and Group I metabotropic glutamate receptors

25 May 2018

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

25 May 2018

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Animal research: reporting in vivo experiments: the ARRIVE guidelines

25 May 2018

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Guidelines for reporting experiments involving animals: the ARRIVE guidelines

25 May 2018

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Group I metabotropic glutamate receptor signalling and its implication in neurological disease

25 May 2018

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Synaptic dysfunction in Parkinson's disease.

25 May 2018

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Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease

25 May 2018

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Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease

25 May 2018

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Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.

25 May 2018

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Neuronal death in Alzheimer's disease and therapeutic opportunities.

25 May 2018

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

25 May 2018

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Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

25 May 2018

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Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

25 May 2018

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Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes

25 May 2018

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The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons

25 May 2018

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Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

25 May 2018

1 reference

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

25 May 2018

1 reference

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PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

25 May 2018

1 reference

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Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

25 May 2018

1 reference

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Regulation of cell death: the calcium-apoptosis link

25 May 2018

1 reference

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Huntingtin in health and disease

25 May 2018

1 reference

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Mutant huntingtin enhances excitotoxic cell death.

25 May 2018

1 reference

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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Cellular survival: a play in three Akts

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

A new generation of Ca2+ indicators with greatly improved fluorescence properties

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Excitotoxic injury of the neostriatum: a model for Huntington's disease

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK pathway

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: implication for ischemia and Huntington's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3687670

15 August 2018

Identifiers

DOI

10.1111/BPH.12164

1 reference

14 November 2017

1 reference

14 November 2017

PubMed publication ID

23489026

1 reference