(Q36263703)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators (English)

1 reference

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7 January 2020

1 reference

2

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7 January 2020

author name string

Andreas Ritzén

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Christian Thomsen

series ordinal

3

1 reference

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7 January 2020

publication date

1 October 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

Basic and Clinical Pharmacology and Toxicology

7 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

97

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

202-213

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16176554%20AND%20SRC:MED&resulttype=core&format=json

SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide

7 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Ligands for glutamate receptors: design and therapeutic prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

"Cushing's disease of the omentum"--fact or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Peripheral glutamate receptors contribute to mechanical hyperalgesia in a neuropathic pain model of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

The disposition, metabolism, and pharmacokinetics of a selective metabotropic glutamate receptor agonist in rats and dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Cloning and characterization of a family C orphan G-protein coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

The distinct role of mGlu1 receptors in post-ischemic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

New perspectives for the development of selective metabotropic glutamate receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Discovery of novel modulators of metabotropic glutamate receptor subtype-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X

Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2005.PTO_156.X