(Q43158706)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20164329%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology (English)

1 reference

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18 January 2020

0 references

1 reference

1 reference

5

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18 January 2020

Jean-Marc Taymans

10

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18 January 2020

Melanie Gérard

1

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18 January 2020

Hans Pottel

7

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18 January 2020

Zeger Debyser

11

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18 January 2020

12

Veerle Baekelandt

1 reference

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18 January 2020

author name string

Veronique Daniëls

3

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18 January 2020

Sarah Schreurs

4

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18 January 2020

Veerle Reumers

6

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18 January 2020

Chris Van den Haute

9

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18 January 2020

Angélique Deleersnijder

2

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18 January 2020

Yves Engelborghs

8

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18 January 2020

language of work or name

English

0 references

publication date

1 February 2010

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18 January 2020

published in

Journal of Neuroscience

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18 January 2020

volume

30

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18 January 2020

issue

7

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18 January 2020

page(s)

2454-2463

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Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts

18 January 2020

cites work

1 reference

12 December 2020

Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506.

1 reference

12 December 2020

Cis peptide bonds in proteins: residues involved, their conformations, interactions and locations

1 reference

12 December 2020

A Drosophila model of Parkinson's disease

1 reference

12 December 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

12 December 2020

Developmental regulation of FKBP65. An ER-localized extracellular matrix binding-protein

1 reference

12 December 2020

Postischemic changes in the immunophilin FKBP12 in the rat brain.

1 reference

12 December 2020

Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons

1 reference

12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

1 reference

12 December 2020

The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons

1 reference

12 December 2020

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

1 reference

12 December 2020

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

1 reference

12 December 2020

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

1 reference

12 December 2020

Immunophilins and their ligands: insights into survival and growth of human neurons

1 reference

12 December 2020

Structural insights into the catalytic mechanism of cyclophilin A

1 reference

12 December 2020

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

1 reference

12 December 2020

Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

1 reference

12 December 2020

Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain

1 reference

12 December 2020

Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein

1 reference

12 December 2020

High brain densities of the immunophilin FKBP colocalized with calcineurin

1 reference

12 December 2020

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

1 reference

12 December 2020

Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases

1 reference

12 December 2020

Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies

1 reference

12 December 2020

Increased bioavailability of tacrolimus after rectal administration in rats

1 reference

12 December 2020

Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease?

1 reference

12 December 2020

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

12 December 2020

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

1 reference

12 December 2020

Pharmacokinetic animal PET study of FK506 as a potent neuroprotective agent.

1 reference

12 December 2020

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

1 reference

12 December 2020

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

12 December 2020

Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506.

1 reference

12 December 2020

Statistically significant dependence of the Xaa-Pro peptide bond conformation on secondary structure and amino acid sequence

1 reference

12 December 2020

Upscaling of lentiviral vector production by tangential flow filtration

1 reference

12 December 2020

Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

1 reference

12 December 2020

Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa.

1 reference

12 December 2020

The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy

1 reference

12 December 2020

Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression

1 reference

12 December 2020

The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia

1 reference

12 December 2020

The human FK506-binding proteins: characterization of human FKBP19

1 reference

12 December 2020

Potentiation of neurite outgrowth and reduction of apoptosis by immunosuppressive agents: implications for neuronal injury and transplantation

1 reference

12 December 2020

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.

1 reference

12 December 2020

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

1 reference

12 December 2020

Screening of immunophilin ligands by quantitative analysis of neurofilament expression and neurite outgrowth in cultured neurons and cells.

1 reference

12 December 2020

Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins

1 reference

12 December 2020

Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy

1 reference

12 December 2020

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T

1 reference

12 December 2020

Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.

1 reference

12 December 2020

Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties

1 reference

12 December 2020

Molecular and cellular biology of synucleins

1 reference

12 December 2020

What's in the pipeline for the treatment of Parkinson's disease?

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12 December 2020

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

1 reference

12 December 2020

Diagnosis and the premotor phase of Parkinson disease

1 reference

12 December 2020

Genomic and proteomic biomarkers for Parkinson disease

1 reference

12 December 2020

Occurrence and role of cis peptide bonds in protein structures

1 reference

12 December 2020

Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain

1 reference

12 December 2020

The subcellular distribution of FK506 binding proteins in rat brain

1 reference

12 December 2020

Functional association of cyclophilin A with HIV-1 virions

1 reference

12 December 2020

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

1 reference

12 December 2020

A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration.

1 reference

12 December 2020

The immunophilin FKBP65 forms an association with the serine/threonine kinase c-Raf-1.

1 reference

12 December 2020

10.1523/JNEUROSCI.5983-09.2010

Identifiers

DOI

1 reference

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18 January 2020

1 reference

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18 January 2020

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