(Q43165899)

15 November 2017

Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity (English)

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15 November 2017

chronic myeloid leukemia

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6

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15 November 2017

5

T P Hughes

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15 November 2017

J R Engler

1

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15 November 2017

A Frede

series ordinal

2

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15 November 2017

V A Saunders

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3

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15 November 2017

A C W Zannettino

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4

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15 November 2017

11 February 2010

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15 November 2017

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15 November 2017

24

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15 November 2017

4

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15 November 2017

765-770

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https://scigraph.springernature.com/pub.10.1038/leu.2010.16

15 November 2017

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cites work

Chromosomal localization of human cellular homologues of two viral oncogenes.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Discontinuation of imatinib therapy after achieving a molecular response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Active transport of imatinib into and out of cells: implications for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

The SLC22 drug transporter family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

hOCT 1 and resistance to imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imatinib in a murine model of chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Regulation of organic cation transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Regulation of the human organic cation transporter hOCT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

CD34+/Ph+ cells are still detectable in chronic myeloid leukemia patients with sustained and prolonged complete cytogenetic remission during treatment with imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

Organic cation transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

inferred from DOI database lookup

7 January 2021

based on heuristic

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

inferred from DOI database lookup

7 January 2021

based on heuristic

Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2010.16

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2010.16

1 reference

Dimensions Publication ID

15 November 2017

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1 reference