(Q43183422)

15 November 2017

The SIN1-PH Domain Connects mTORC2 to PI3K. (English)

1 reference

15 November 2017

Hai-Xin Yuan

1

1 reference

PMCID

4638136

15 November 2017

Kun-Liang Guan

series ordinal

2

1 reference

15 November 2017

1 November 2015

1 reference

15 November 2017

1 reference

15 November 2017

5

1 reference

15 November 2017

11

1 reference

15 November 2017

1127-1129

1 reference

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

15 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

mTORC2 targets AGC kinases through Sin1-dependent recruitment

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638136

10.1158/2159-8290.CD-15-1125

15 August 2018

Identifiers

DOI

1 reference

15 November 2017

1 reference

15 November 2017

1 reference

PMCID

4638136