(Q39497163)

12 September 2017

title

mTORC2 targets AGC kinases through Sin1-dependent recruitment (English)

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12 September 2017

Adrian T Saurin

3

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Mark Linch

object named as

Mark D Linch

Peter Joseph Jacques Parker

2

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object named as

Peter J Parker

5

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author name string

Angus J M Cameron

1

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12 September 2017

Cristina Escribano

4

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12 September 2017

language of work or name

English

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publication date

1 October 2011

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12 September 2017

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12 September 2017

volume

439

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12 September 2017

issue

2

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12 September 2017

page(s)

287-297

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TOR signaling in growth and metabolism

12 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110678

TOR regulation of AGC kinases in yeast and mammals

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Multiple pathways control protein kinase C phosphorylation

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Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

21 January 2018

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

21 January 2018

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mTOR complex 2 in adipose tissue negatively controls whole-body growth

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PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

21 January 2018

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Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon

21 January 2018

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The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis

21 January 2018

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PKC epsilon controls the traffic of beta1 integrins in motile cells

21 January 2018

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 January 2018

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Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

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Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.

21 January 2018

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Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

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Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

21 January 2018

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Regulation of novel protein kinase C epsilon by phosphorylation.

21 January 2018

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mTOR and cancer: insights into a complex relationship

21 January 2018

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

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Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

21 January 2018

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Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

21 January 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

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Protein kinase C - a family of protein kinases, allosteric effectors or both?

21 January 2018

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Identification and characterization of a constitutively T-loop phosphorylated and active recombinant S6K1: expression, purification, and enzymatic studies in a high capacity non-radioactive TR-FRET Lance assay

21 January 2018

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Activation of mTORC2 by association with the ribosome

21 January 2018

1 reference

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1042/BJ20110678

1 reference

12 September 2017

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