(Q42908351)

10 November 2017

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis (English)

1 reference

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

10 November 2017

1 reference

corrigendum / erratum

1 reference

5

1 reference

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3 June 2020

Byeong Mo Kim

12

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3 June 2020

13

Shavali Shaik

1 reference

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3 June 2020

21

Wenyi Wei

1 reference

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3 June 2020

3

Hiroyuki Inuzuka

1 reference

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3 June 2020

8

Lixin Wan

1 reference

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3 June 2020

17

John M Asara

1 reference

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3 June 2020

19

John Blenis

1 reference

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3 June 2020

author name string

Pengda Liu

1

1 reference

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3 June 2020

Wenjian Gan

2

1 reference

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3 June 2020

Adam S Lazorchak

4

1 reference

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3 June 2020

Omotooke Arojo

6

1 reference

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3 June 2020

Dou Liu

7

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3 June 2020

Bo Zhai

9

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3 June 2020

Yonghao Yu

10

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3 June 2020

Min Yuan

11

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3 June 2020

Suchithra Menon

14

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3 June 2020

Tae Ho Lee

16

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3 June 2020

Brendan D Manning

18

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3 June 2020

Bing Su

20

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3 June 2020

Steven P Gygi

15

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3 June 2020

publication date

27 October 2013

1 reference

10 November 2017

1 reference

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3 June 2020

volume

15

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3 June 2020

issue

11

1 reference

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3 June 2020

page(s)

1340-1350

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https://scigraph.springernature.com/pub.10.1038/ncb2860

3 June 2020

exact match

0 references

cites work

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27 May 2018

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27 May 2018

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27 May 2018

1 reference

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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mTOR signaling in growth control and disease

27 May 2018

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A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision

27 May 2018

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mTOR signaling in disease

27 May 2018

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Integrated genomic analyses of ovarian carcinoma

27 May 2018

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

27 May 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

27 May 2018

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Akt, FoxO and regulation of apoptosis

27 May 2018

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27 May 2018

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A tissue-specific atlas of mouse protein phosphorylation and expression

27 May 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

27 May 2018

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FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

27 May 2018

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Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

27 May 2018

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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

27 May 2018

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Transcriptional control of preadipocyte determination by Zfp423.

27 May 2018

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Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor

27 May 2018

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Rictor is a novel target of p70 S6 kinase-1.

27 May 2018

1 reference

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COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

27 May 2018

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Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

27 May 2018

1 reference

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mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex

27 May 2018

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Molecular mechanisms of mTOR-mediated translational control

27 May 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

27 May 2018

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Defining the role of mTOR in cancer

27 May 2018

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

27 May 2018

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TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

27 May 2018

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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

27 May 2018

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

27 May 2018

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

27 May 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

27 May 2018

1 reference

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

27 May 2018

1 reference

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

27 May 2018

1 reference

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

27 May 2018

1 reference

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mTOR and cancer: insights into a complex relationship

27 May 2018

1 reference

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TOR signaling in growth and metabolism

27 May 2018

1 reference

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An expanding role for mTOR in cancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Dysregulation of the TSC-mTOR pathway in human disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

27 May 2018

1 reference

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

27 May 2018

The Hallmarks of Cancer

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Signal transduction and signaling networks

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

mTORC2 is the hydrophobic motif kinase for SGK1.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Activation of a GST-tagged AKT2/PKBbeta

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827117

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

16 August 2018

1 reference

The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration

21 January 2018

1 reference

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

21 January 2018

1 reference

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 January 2018

1 reference

Transformation of human and murine fibroblasts without viral oncoproteins

21 January 2018

1 reference

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

Cellular senescence: when bad things happen to good cells

21 January 2018

1 reference

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NCB2860

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24161930%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24161930%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

24161930

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24161930%20AND%20SRC:MED&resulttype=core&format=json