(Q43245922)

English

Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery

scientific article published in October 2006

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scholarly article

1 reference

Europe PubMed Central

17 November 2017

Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery (English)

1 reference

Europe PubMed Central

17 November 2017

0 references

1 reference

based on heuristic

inferred from title

author name string

Manoj K Ramjee

1

1 reference

Europe PubMed Central

17 November 2017

Nicholas S Flinn

2

1 reference

Europe PubMed Central

17 November 2017

Tracy P Pemberton

3

1 reference

Europe PubMed Central

17 November 2017

Martin Quibell

4

1 reference

Europe PubMed Central

17 November 2017

Yikang Wang

5

1 reference

Europe PubMed Central

17 November 2017

John P Watts

6

1 reference

Europe PubMed Central

17 November 2017

language of work or name

0 references

publication date

1 October 2006

1 reference

Europe PubMed Central

17 November 2017

Biochemical Journal

1 reference

Europe PubMed Central

17 November 2017

399

1 reference

Europe PubMed Central

17 November 2017

1

1 reference

Europe PubMed Central

17 November 2017

47-57

1 reference

Europe PubMed Central

17 November 2017

The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Antimalarial drug discovery: efficacy models for compound screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax

1 reference

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25 May 2018

DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS

1 reference

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25 May 2018

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

1 reference

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25 May 2018

Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Genome sequence of the human malaria parasite Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

1 reference

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25 May 2018

Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Human malaria in immunocompromised mice: new in vivo model for chemotherapy studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Azepanone-based inhibitors of human and rat cathepsin K

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Azapeptides as inhibitors and active site titrants for cysteine proteinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Design of potent and selective human cathepsin K inhibitors that span the active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Kinetics of the inhibition of thrombin by hirudin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

The behavior and significance of slow-binding enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

25 May 2018

Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Differences in biochemical properties of the Plasmodial falcipain-2 and berghepain-2 orthologues: implications for in vivo screens of inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors

1 reference

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Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.

1 reference

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15 August 2018

Cloning and sequence characterisation of falcipain-2 from Plasmodium falciparum Gombak A strain (Malaysia).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Vinyl sulfones as mechanism-based cysteine protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570174

15 August 2018

Mechanism of inhibition of cathepsin K by potent, selective 1, 5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16776649

12 December 2020

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inferred from PubMed ID database lookup

Anthranilamide and nitrotyrosine as a donor-acceptor pair in internally quenched fluorescent substrates for endopeptidases: multicolumn peptide synthesis of enzyme substrates for subtilisin Carlsberg and pepsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16776649

12 December 2020

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inferred from PubMed ID database lookup

5-(hydroxymethyl)oxazoles: versatile scaffolds for combinatorial solid-phase synthesis of 5-substituted oxazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16776649

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20060422

1 reference

Europe PubMed Central

17 November 2017

1 reference

Europe PubMed Central

17 November 2017

1 reference

Europe PubMed Central

17 November 2017

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