(Q43248374)

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A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

scientific article published on 5 November 2009

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17 November 2017

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells (English)

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17 November 2017

chronic myeloid leukemia

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Oliver Hantschel

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17 November 2017

Michael C. Heinrich

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Giulio Superti-Furga

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Harald Herrmann

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H Herrmann

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U Rix

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17 November 2017

L L Remsing Rix

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A S Terker

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N V Fernbach

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M Planyavsky

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F P Breitwieser

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J Colinge

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K L Bennett

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M Augustin

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J H Till

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P Valent

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5 November 2009

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44-50

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17 November 2017

https://scigraph.springernature.com/pub.10.1038/leu.2009.228

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NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia

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Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase

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BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

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21 January 2018

Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

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21 January 2018

INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity.

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21 January 2018

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

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Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

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Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

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The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

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Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA

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The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

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PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

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Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives

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Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation

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Lipocalin 2 is required for BCR-ABL-induced tumorigenesis

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Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

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Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity

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Eph-ephrin bidirectional signaling in physiology and disease

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Eph, a protein family coming of age: more confusion, insight, or complexity?

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EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

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ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.

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ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells

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A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development

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Sensitivity of human cells bearing oncogenic mutant kit isoforms to the novel tyrosine kinase inhibitor INNO-406

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Neutrophil gelatinase-associated lipocalin expression in chronic myeloid leukemia

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10.1038/LEU.2009.228

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Europe PubMed Central

PubMed publication ID

17 November 2017

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Europe PubMed Central

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17 November 2017

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