(Q43257608)

17 November 2017

title

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes (English)

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17 November 2017

2

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17 November 2017

K Murai

1

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17 November 2017

K Nakagawa

series ordinal

3

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17 November 2017

R Kawai

series ordinal

4

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17 November 2017

T Kamataki

series ordinal

5

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17 November 2017

language of work or name

English

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publication date

1 November 2009

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17 November 2017

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17 November 2017

volume

39

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17 November 2017

issue

11

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17 November 2017

page(s)

795-802

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Aromatase inhibition and its pharmacologic implications

17 November 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Cytochromes P450, drugs, and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

High-performance liquid chromatography of the aromatase inhibitor, letrozole, and its metabolite in biological fluids with automated liquid-solid extraction and fluorescence detection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Clinical importance of the cytochromes P450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Summary of information on human CYP enzymes: human P450 metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Comparative bioavailability of letrozole under fed and fasting conditions in 12 healthy subjects after a 2.5 mg single oral administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498250903171395

10.3109/00498250903171395

21 January 2018

Identifiers

DOI

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17 November 2017

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