(Q37414581)

English

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro

scientific article published on 07 February 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Zeruesenay Desta

4

object named as

Zeruesenay Desta

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Seongwook Jeong

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Margaret M Woo

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

David A Flockhart

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

7 February 2009

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

64

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

867-875

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

https://scigraph.springernature.com/pub.10.1007/s00280-009-0935-7

0 references

Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

The discovery and mechanism of action of letrozole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

Letrozole : in postmenopausal hormone-responsive early-stage breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

Estrogen carcinogenesis in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

Aromatase inhibitors in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

CYP2A6 genetic variation and potential consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

6 September 2017

Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

26 June 2018

Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

26 June 2018

Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

26 June 2018

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

26 June 2018

Summary of aromatase inhibitor clinical trials in postmenopausal women with early breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

2 September 2018

Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

2 September 2018

Biotransformation of letrozole in rat liver microsomes: effects of gender and tamoxifen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

2 September 2018

A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

2 September 2018

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

2 September 2018

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774495

2 September 2018

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of coumarin 7-hydroxylase activity in human liver microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absolute bioavailability of letrozole in healthy postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of human cytochrome P450 isoforms interacting with pimozide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma protein binding of letrozole, a new nonsteroidal aromatase enzyme inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen in the treatment of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological aromatization of steroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gender difference in letrozole pharmacokinetics in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19198839

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-009-0935-7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

ResearchGate publication ID

0 references

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