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CYP2A6 genetic variation and potential consequences
scientific article (publication date: 18 November 2002)
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
CYP2A6 genetic variation and potential consequences
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
main subject
genetic variation
1 reference
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inferred from title
author
Edward M. Sellers
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
Rachel F Tyndale
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
Chun Xu
series ordinal
1
object named as
Chun Xu
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
author name string
Shari Goodz
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
language of work or name
English
0 references
publication date
1 November 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
published in
Advanced Drug Delivery Reviews
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
volume
54
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
issue
10
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
page(s)
1245-1256
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
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Comparison of CYP2A6 catalytic activity on coumarin 7-hydroxylation in human and monkey liver microsomes
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The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
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Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19
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Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation
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Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking
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Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase
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Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans
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The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP
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Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.
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An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles
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A novel single nucleotide polymorphism altering stability and activity of CYP2a6
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CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity
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CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians
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A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
1 reference
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Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.
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Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population
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Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity
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Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay
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7 January 2021
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7 January 2021
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7 January 2021
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The genetics of smoking persistence in men and women: a multicultural study
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7 January 2021
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Common genetic vulnerability for nicotine and alcohol dependence in men
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Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior
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Nicotine metabolism defect reduces smoking
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The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit
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Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
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7 January 2021
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CYP2A6 gene deletion reduces susceptibility to lung cancer
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7 January 2021
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Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.
1 reference
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7 January 2021
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Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population
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7 January 2021
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7 January 2021
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7 January 2021
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7 January 2021
based on heuristic
inferred from DOI database lookup
A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).
1 reference
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7 January 2021
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Expression of cytochrome P450 2A6 in Escherichia coli: purification, spectral and catalytic characterization, and preparation of polyclonal antibodies
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Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6).
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Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen
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Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C.
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Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0169-409X(02)00065-0
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
PubMed ID
12406643
1 reference
stated in
Europe PubMed Central
PubMed ID
12406643
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12406643%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 December 2019
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