(Q43263389)

17 November 2017

title

Azetidinones as zinc-binding groups to design selective HDAC8 inhibitors (English)

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17 November 2017

5

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17 November 2017

Arianna Quintavalla

2

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author name string

Paola Galletti

1

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17 November 2017

Caterina Ventrici

3

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17 November 2017

Giuseppe Giannini

4

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17 November 2017

Sergio Penco

6

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17 November 2017

Grazia Gallo

7

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17 November 2017

Silvia Vincenti

8

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17 November 2017

Daria Giacomini

9

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17 November 2017

publication date

1 December 2009

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17 November 2017

number of pages

11

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inferred from page(s)

published in

ChemMedChem

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17 November 2017

volume

4

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17 November 2017

issue

12

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17 November 2017

page(s)

1991-2001

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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

17 November 2017

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Cloning and characterization of a novel human histone deacetylase, HDAC8

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Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues

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Histone deacetylase 8 in neuroblastoma tumorigenesis

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The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain

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Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

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A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

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Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

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Identification of novel isoform-selective inhibitors within class I histone deacetylases

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Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

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Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity

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N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors

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Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors

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Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

21 January 2018

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

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3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors

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Titanocene(III)-catalyzed formation of indolines and azaindolines

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Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases

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7 January 2021

Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility.

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7 January 2021

HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

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7 January 2021

Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors

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7 January 2021

Inhibitory effect by new monocyclic 4-alkyliden-beta-lactam compounds on human platelet activation

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7 January 2021

Synthesis of 3-alkoxycarbonyl-1beta-methylcarbapenem by using the palladium-catalyzed C-N bond-forming reaction between vinyl halide and beta-lactam nitrogen

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7 January 2021

Diastereoselective alkylation of beta-amino esters: structural and rate studies reveal alkylations of hexameric lithium enolates

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200900309

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17 November 2017

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