(Q43269412)

English

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.

scientific article published on 30 September 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Pietro Formisano

13

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Guido Iaccarino

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

F Oriente

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

S Iovino

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A Cassese

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

C Romano

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

C Miele

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

G Troncone

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

M Balletta

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A Perfetti

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

G Santulli

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

R Valentino

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

F Beguinot

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

30 September 2009

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

52

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

2642-2652

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C (PKC) beta modulates serine phosphorylation of insulin receptor substrate-1 (IRS-1)--effect of overexpression of PKCbeta on insulin signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factors and the development of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microvascular complications of impaired glucose tolerance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into TGF-beta-Smad signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: the DCCT/EDIC Genetics Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta signal transduction and progressive renal disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microalbuminuria precedes the development of NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene and protein markers of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microvascular disease: what does the UKPDS tell us about diabetic nephropathy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta and Smad signalling in kidney diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of protein kinase C activation and the vascular complications of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated plasma levels of transforming growth factor-beta 1 in NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial alpha1-adrenoceptors regulate neo-angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation analysis of diabetic nephropathy in Pima Indians

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse models of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A primary culture of mouse proximal tubular cells, established on collagen-coated membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of PEA-15, a major substrate for protein kinase C in astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation analysis of urinary albumin excretion in families with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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