(Q43280141)

18 November 2017

title

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa (English)

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18 November 2017

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5

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18 November 2017

Nicholas J Hawkins

1

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author name string

James H-F Lee

2

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18 November 2017

Justin J-L Wong

3

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18 November 2017

Chau-To Kwok

4

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18 November 2017

Megan P Hitchins

6

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18 November 2017

publication date

4 September 2009

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18 November 2017

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18 November 2017

volume

22

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18 November 2017

issue

12

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18 November 2017

page(s)

1588-1599

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https://scigraph.springernature.com/pub.10.1038/modpathol.2009.130

18 November 2017

exact match

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

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Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.

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Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer

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Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

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Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.

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Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

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MGMT promoter methylation and field defect in sporadic colorectal cancer.

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Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer

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MGMT: its role in cancer aetiology and cancer therapeutics

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Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.

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Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma

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O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions

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Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.

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Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype.

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CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer.

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Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points

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CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

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Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample

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Serrated adenoma of the colorectum and the DNA-methylator phenotype

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CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.

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Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin

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7 January 2021

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer

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Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene

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Microsatellite instability and the clinicopathological features of sporadic colorectal cancer

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CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.

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Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers

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Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2009.130

7 January 2021

Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2009.130

7 January 2021

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

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7 January 2021

Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.

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10.1038/MODPATHOL.2009.130

Identifiers

DOI

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Dimensions Publication ID

18 November 2017

1033794136

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