(Q35790060)

10 August 2017

title

Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer (English)

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10 August 2017

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Edward J Fox

1

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10 August 2017

Dermot T Leahy

2

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10 August 2017

Robert Geraghty

3

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10 August 2017

Hugh E Mulcahy

4

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10 August 2017

David Fennelly

5

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10 August 2017

John M Hyland

6

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10 August 2017

Diarmuid P O'Donoghue

7

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10 August 2017

Kieran Sheahan

8

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10 August 2017

publication date

1 February 2006

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The Journal of Molecular Diagnostics

10 August 2017

published in

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10 August 2017

volume

8

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10 August 2017

issue

1

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10 August 2017

page(s)

68-75

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O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions

10 August 2017

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12 July 2018

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O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

12 July 2018

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

12 July 2018

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Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

12 July 2018

1 reference

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Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability

12 July 2018

1 reference

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Mismatch repair defects in human carcinogenesis

12 July 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

12 July 2018

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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

12 July 2018

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12 July 2018

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12 July 2018

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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

12 July 2018

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A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells

12 July 2018

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On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line

12 July 2018

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Hypermethylation of the DNA repair gene MGMT: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors

12 July 2018

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25 September 2018

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Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

25 September 2018

1 reference

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DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Frameshift mutator mutations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867561

Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent

15 November 2018

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12 December 2020

Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability

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12 December 2020

Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal cancers with microsatellite instability

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12 December 2020

The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation

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12 December 2020

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

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12 December 2020

A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

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12 December 2020

Peritoneal Involvement in Stage II Colon Cancer

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12 December 2020

The clinical significance of invasion of veins by rectal cancer

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12 December 2020

Venous and nerve invasion as prognostic factors in postoperative survival of patients with resectable cancer of the rectum

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12 December 2020

A new prognostic classification of rectal cancer

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12 December 2020

10.2353/JMOLDX.2006.050084

Identifiers

DOI

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10 August 2017

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10 August 2017

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