(Q43289218)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693765%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines? (English)

1 reference

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5 February 2020

1

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5 February 2020

author name string

Joscha Kotthaus

2

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5 February 2020

Helen Hungeling

3

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5 February 2020

Jürke Kotthaus

4

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5 February 2020

Bernd Clement

5

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5 February 2020

publication date

1 October 2009

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5 February 2020

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5 February 2020

volume

4

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5 February 2020

issue

10

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5 February 2020

page(s)

1595-1599

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Lessons learned from marketed and investigational prodrugs

5 February 2020

cites work

1 reference

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7 January 2021

Arginine mimetic structures in biologically active antagonists and inhibitors

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7 January 2021

Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies

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7 January 2021

Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines

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7 January 2021

Biotransformation of benzamidine and benzamidoxime in vivo

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7 January 2021

Reduction of amidoxime derivatives to pentamidine in vivo

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7 January 2021

Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug

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7 January 2021

The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs

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7 January 2021

Microsomal catalyzed N-hydroxylation of guanabenz and reduction of the N-hydroxylated metabolite: characterization of the two reactions and genotoxic potential of guanoxabenz

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Metabolism of N-hydroxyguanidines (N-hydroxydebrisoquine) in human and porcine hepatocytes: reduction and formation of glucuronides

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7 January 2021

Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme

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7 January 2021

Chemical oxidation of N-hydroxyguanidine compounds. Release of nitric oxide, nitroxyl and possible relationship to the mechanism of biological nitric oxide generation

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7 January 2021

Oxidation of N-hydroxyguanidines by copper(II): model systems for elucidating the physiological chemistry of the nitric oxide biosynthetic intermediate N-hydroxyl-L-arginine

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7 January 2021

In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis

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7 January 2021

Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives

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7 January 2021

Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability

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7 January 2021

Diacetyldiamidoximeester of pentamidine, a prodrug for treatment of protozoal diseases: synthesis, in vitro and in vivo biotransformation.

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7 January 2021

Orally active GPIIb/IIIa antagonists: synthesis and biological activities of masked amidines as prodrugs of 2-[(3S)-4.

1 reference

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7 January 2021

Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.

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7 January 2021

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

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7 January 2021

Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa

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7 January 2021

Oxidative activation of acylguanidine prodrugs: intestinal presystemic activation in rats limits absorption and can be inhibited by co-administration of ketoconazole

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7 January 2021

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

The 108-kDA peptidylglycine alpha-amidating monooxygenase precursor contains two separable enzymatic activities involved in peptide amidation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Two enzymes concerned in peptide hormone α-amidation are synthesized from a single mRNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Characterization of a peptide alpha-amidation activity in human plasma and tissues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Novel substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Amidation of Salicyluric Acid and Gentisuric Acid: A Possible Role for Peptidylglycine α-Amidating Monooxygenase in the Metabolism of Aspirin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

A new proposal for the mechanism of glycine hydroxylation as catalyzed by peptidylglycine alpha-hydroxylating monooxygenase (PHM).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Aromatic diamidines as antiparasitic agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Selective inactivation of the hydroxylase activity of bifunctional rat peptidylglycine alpha-amidating enzyme

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900233

7 January 2021

Identifiers

DOI

10.1002/CMDC.200900233

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19693765%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference