(Q44403639)

English

Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug

scientific article published on May 1, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Characterization of in vitro biotransformation of new, orally active, direct thrombin inhibitor ximelagatran, an amidoxime and ester prodrug (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug (English)

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

pharmaceutical science

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

author name string

Bernd Clement

1

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Katrin Lopian

2

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12695354

24 December 2023

publication date

1 May 2003

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

full work available at URL

https://syndication.highwire.org/content/doi/10.1124/dmd.31.5.645

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

31

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

645-651

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Enzyme localization in the inner and outer membranes of rat liver mitochondria

2

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines

4

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Microsomal catalyzed N-hydroxylation of guanabenz and reduction of the N-hydroxylated metabolite: characterization of the two reactions and genotoxic potential of guanoxabenz

5

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Reduction of amidoxime derivatives to pentamidine in vivo

7

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Isolation and Characterization of the Protein Components of the Liver Microsomal O2-insensitive NADH-Benzamidoxime Reductase

8

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

10-alpha-Aminoacyl-9(10H)-anthracenones: inhibition of 12(S)-HETE biosynthesis and HaCaT cell growth

9

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Enzymatic reduction of benzamidoxime to benzamidine

10

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

13

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

15

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Pharmacokinetics of an emerging new class of anticoagulant/antithrombotic drugs. A review of small-molecule thrombin inhibitors

16

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range

18

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6.

19

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Warfarin Sodium versus Low-Dose Heparin in the Long-Term Treatment of Venous Thrombosis

20

1 reference

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24 December 2023

Orally active GPIIb/IIIa antagonists: synthesis and biological activities of masked amidines as prodrugs of 2-[(3S)-4.

21

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Localization of L-lactate dehydrogenase in mitochondria.

22

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy

24

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

The reduction potential of cytochrome b5 is modulated by its exposed heme edge

25

1 reference

10.1124/DMD.31.5.645

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24 December 2023

In vitro intestinal permeability of factor Xa inhibitors: influence of chemical structure on passive transport and susceptibility to efflux

26

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Measurement of protein using bicinchoninic acid

27

1 reference

10.1124/DMD.31.5.645

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24 December 2023

An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study

28

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450

29

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Property-based design: optimization of drug absorption and pharmacokinetics

30

1 reference

10.1124/DMD.31.5.645

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24 December 2023

Effect of heme orientation on the reduction potential of cytochrome b5

31

1 reference

10.1124/DMD.31.5.645

https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines

32

1 reference

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https://api.crossref.org/works/10.1124/DMD.31.5.645

24 December 2023

Identifiers

10.1124/DMD.31.5.645

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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