(Q34819107)

4 August 2017

1 reference

title

Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy (English)

1 reference

4 August 2017

0 references

1 reference

1

Laurence H Patterson

1 reference

PubMed ID

12214668

4 August 2017

language of work or name

English

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publication date

1 August 2002

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4 August 2017

Drug Metabolism Reviews

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4 August 2017

34

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4 August 2017

3

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4 August 2017

581-592

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Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

4 August 2017

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Hypoxia and the regulation of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Chemical radiosensitization of hypoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

The experimental development of bioreductive drugs and their role in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

An improved method of encapsulation of doxorubicin in liposomes: pharmacological, toxicological and therapeutic evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

The human CYP3A subfamily: practical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Role of nitric oxide in tumour progression: lessons from human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Nitric oxide synthase activity in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

A NIH/3T3 cell line stably expressing human cytochrome P450-3A4 used in combination with a lacZ' shuttle vector to study mutagenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

Pharmacogenetic determinants of anti-cancer drug activity and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005659

21 January 2018

Identifiers

DOI

10.1081/DMR-120005659

1 reference

4 August 2017

1 reference

PubMed ID

12214668