(Q43423481)

23 November 2017

Allosteric regulation of PKM2 allows cellular adaptation to different physiological states (English)

1 reference

23 November 2017

Dan Y Gui

1

1 reference

PubMed ID

23423437

23 November 2017

Caroline A Lewis

series ordinal

2

1 reference

PubMed ID

23423437

23 November 2017

Matthew G Vander Heiden

series ordinal

3

1 reference

23 November 2017

19 February 2013

1 reference

23 November 2017

1 reference

23 November 2017

6

1 reference

23 November 2017

263

1 reference

23 November 2017

pe7

1 reference

Regulation of cancer cell metabolism

23 November 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003925

10.1126/SCISIGNAL.2003925

21 January 2018

Identifiers

DOI

1 reference

23 November 2017

1 reference

PubMed ID

23423437