(Q43464822)

23 November 2017

title

Targeting leukotriene B4 in inflammation (English)

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23 November 2017

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Antonio Di Gennaro

1

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23 November 2017

Jesper Z Haeggström

series ordinal

2

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23 November 2017

language of work or name

English

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publication date

4 October 2013

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Expert Opinion on Therapeutic Targets

23 November 2017

published in

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23 November 2017

volume

18

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23 November 2017

issue

1

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23 November 2017

page(s)

79-93

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Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

23 November 2017

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Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis

21 January 2018

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Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice

21 January 2018

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Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention.

21 January 2018

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21 January 2018

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21 January 2018

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Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability

21 January 2018

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21 January 2018

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21 January 2018

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The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cytosolic phospholipase A2

21 January 2018

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The structure of human 5-lipoxygenase

21 January 2018

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Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.

21 January 2018

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5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation

21 January 2018

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A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

21 January 2018

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Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

21 January 2018

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Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4

21 January 2018

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Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation

21 January 2018

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Expression of functional leukotriene B4 receptors on human airway smooth muscle cells

21 January 2018

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A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.843671

Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2

21 January 2018

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12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2

21 January 2018

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Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis

21 January 2018

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Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia

21 January 2018

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Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.843671

Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis

21 January 2018

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Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model

21 January 2018

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A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice

21 January 2018

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21 January 2018

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21 January 2018

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Protection from pulmonary fibrosis in leukotriene-deficient mice

21 January 2018

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Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice

21 January 2018

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Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome.

21 January 2018

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MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease

21 January 2018

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21 January 2018

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The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma

21 January 2018

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Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

21 January 2018

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21 January 2018

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21 January 2018

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Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis

21 January 2018

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Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase

21 January 2018

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Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness

21 January 2018

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Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension

21 January 2018

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Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.

21 January 2018

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Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: preclinical and clinical developments

21 January 2018

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Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice.

21 January 2018

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Leukotriene receptor antagonists in children with cystic fibrosis lung disease : anti-inflammatory and clinical effects.

21 January 2018

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Release of anti-HIV mediators after administration of leukotriene B4 to humans

21 January 2018

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Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

21 January 2018

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Subcellular localization of leukotriene receptors in human endothelial cells.

21 January 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

21 January 2018

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Leukotrienes are potent constrictors of human bronchi

21 January 2018

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Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

21 January 2018

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Role of cytosolic phospholipase A2 in allergic response and parturition

21 January 2018

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10.1517/14728222.2013.843671

21 January 2018

Identifiers

DOI

1 reference

23 November 2017

1 reference