(Q43492573)

24 November 2017

title

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6. (English)

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24 November 2017

11

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24 November 2017

6

Jin Seok Park

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24 November 2017

13

Seok Hee Park

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24 November 2017

7

Youn Sook Lee

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24 November 2017

1

Su Myung Jung

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24 November 2017

8

Jun Hwan Kim

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24 November 2017

10

Yoe-Sik Bae

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24 November 2017

2

Ji-Hyung Lee

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24 November 2017

Jinyoung Park

3

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24 November 2017

Young Sun Oh

4

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24 November 2017

Sung Kyun Lee

5

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24 November 2017

Jae Young Lee

9

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24 November 2017

Seong-Jin Kim

12

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24 November 2017

language of work or name

English

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publication date

1 January 2013

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24 November 2017

published in

Nature Communications

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24 November 2017

volume

4

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24 November 2017

page(s)

2562

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https://scigraph.springernature.com/pub.10.1038/ncomms3562

24 November 2017

exact match

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cites work

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Smad transcription factors

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The regulation of TGFbeta signal transduction

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

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TGFbeta signalling: a complex web in cancer progression

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Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF.

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TGF-beta signaling: positive and negative effects on tumorigenesis

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Non-Smad pathways in TGF-beta signaling

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7 January 2021

Non-Smad signaling pathways

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

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7 January 2021

The TAK1-TRAF6 signalling pathway

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Role of transforming growth factor beta in human disease

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7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

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7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily

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7 January 2021

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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7 January 2021

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

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Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-beta1-induced negative regulation of IL-1R/TLR signaling

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Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.

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Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

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USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

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The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

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7 January 2021

Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3

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7 January 2021

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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7 January 2021

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

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7 January 2021

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation

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7 January 2021

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

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7 January 2021

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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7 January 2021

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling

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7 January 2021

Direct, noncatalytic mechanism of IKK inhibition by A20.

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7 January 2021

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

A20: linking a complex regulator of ubiquitylation to immunity and human disease

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7 January 2021

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Non-Smad TGF-beta signals

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.

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7 January 2021

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis

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7 January 2021

A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Hepatocyte Death: A Clear and Present Danger

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Pattern recognition receptors and inflammation

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https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS3562

7 January 2021

Identifiers

DOI

10.1038/NCOMMS3562

1 reference

24 November 2017

0 references

1 reference