(Q43515530)

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The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia.

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20 January 2020

The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia (English)

1 reference

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20 January 2020

phosphorylation

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Marina Bousquet

4

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20 January 2020

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N Gallay

1

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20 January 2020

C Dos Santos

2

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20 January 2020

L Cuzin

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20 January 2020

V Simmonet Gouy

5

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20 January 2020

C Chaussade

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20 January 2020

M Attal

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20 January 2020

B Payrastre

8

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20 January 2020

C Demur

9

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20 January 2020

C Récher

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20 January 2020

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22 January 2009

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20 January 2020

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20 January 2020

23

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20 January 2020

1029-1038

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20 January 2020

6

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20 January 2020

https://scigraph.springernature.com/pub.10.1038/leu.2008.395

0 references

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

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Frequent detection of the JAK2 V617F mutation in bone marrow core biopsy specimens from chronic myeloproliferative disorders using the TaqMan polymerase chain reaction single nucleotide polymorphism genotyping assay: a retrospective study with patho

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

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The human bladder carcinoma cell line 5637 constitutively secretes functional cytokines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

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A critical role for Lyn in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessment of somatic mutations in phosphatidylinositol 3-kinase gene in human lymphoma and acute leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110delta mutations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Class reunion: PTEN joins the nuclear crew.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of the PTEN tail regulates protein stability and function

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of protein kinase cascades by protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

The selectivity of protein kinase inhibitors: a further update

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms controlling pathogenesis and survival of leukemic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular signaling: pivoting around PDK-1.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of PKC and PDK1 in monocyte lineage specification by Ras

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Survival of acute myeloid leukemia cells requires PI3 kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53 pathway: positive and negative feedback loops

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.395

7 January 2021

based on heuristic

inferred from DOI database lookup

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

1 reference

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An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

1 reference

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based on heuristic

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Identifiers

10.1038/LEU.2008.395

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19158829%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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1 reference

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20 January 2020

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