(Q43590670)

25 November 2017

title

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop (English)

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25 November 2017

Zhou A

1

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25 November 2017

Carrell RW

series ordinal

2

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25 November 2017

Huntington JA

series ordinal

3

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25 November 2017

language of work or name

English

0 references

publication date

26 April 2001

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Journal of Biological Chemistry

25 November 2017

published in

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25 November 2017

volume

276

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25 November 2017

issue

29

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25 November 2017

page(s)

27541-27547

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What can the structures of enzyme-inhibitor complexes tell us about the structures of enzyme substrate complexes?

25 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102594200

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

21 January 2018

1 reference

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A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

21 January 2018

1 reference

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Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

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Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

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Genomic and cDNA cloning of the human C1 inhibitor. Intron-exon junctions and comparison with other serpins

21 January 2018

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Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases

21 January 2018

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Alpha 2-antiplasmin Enschede: alanine insertion and abolition of plasmin inhibitory activity

21 January 2018

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Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

21 January 2018

1 reference

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Renaturation, purification, and characterization of human plasminogen activator inhibitor type 2 (PAI-2) accumulated at high level in Escherichia coli.

21 January 2018

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Polymerization of plasminogen activator inhibitor-1.

21 January 2018

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Isolation and properties of human plasma α-1-proteinase inhibitor

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.

21 January 2018

1 reference

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The P6−P2 Region of Serpins Is Critical for Proteinase Inhibition and Complex Stability

21 January 2018

1 reference

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Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations

21 January 2018

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On the size of the active site in proteases. I. Papain

21 January 2018

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Structural basis of the activation and action of trypsin

21 January 2018

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Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

21 January 2018

1 reference

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Trypsin complexed with α1‐proteinase inhibitor has an increased structural flexibility

21 January 2018

1 reference

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Apparent formation of sodium dodecyl sulfate-stable complexes between serpins and 3,4-dichloroisocoumarin-inactivated proteinases is due to regeneration of active proteinase from the inactivated enzyme

21 January 2018

1 reference

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Protein engineering of chimeric Serpins: an investigation into effects of the serpin scaffold and reactive centre loop length

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M102594200

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25 November 2017

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