(Q43629514)

25 November 2017

title

Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy (English)

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25 November 2017

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6

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25 November 2017

R A Spooner

1

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25 November 2017

K A Maycroft

2

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25 November 2017

H Paterson

3

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25 November 2017

F Friedlos

4

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25 November 2017

C J Springer

5

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25 November 2017

language of work or name

English

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publication date

1 July 2001

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International Journal of Cancer

25 November 2017

published in

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25 November 2017

volume

93

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25 November 2017

issue

1

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25 November 2017

page(s)

123-130

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Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

25 November 2017

cites work

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Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

21 January 2018

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The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

21 January 2018

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

21 January 2018

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Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

21 January 2018

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The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice.

21 January 2018

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The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

21 January 2018

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The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

21 January 2018

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Selective cell ablation in transgenic mice expression E. coli nitroreductase

21 January 2018

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Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

21 January 2018

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Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species

21 January 2018

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A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

21 January 2018

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Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

21 January 2018

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Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme

21 January 2018

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Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

21 January 2018

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CB 1954 revisited. I. Disposition kinetics and metabolism

21 January 2018

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In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug

21 January 2018

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Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)

21 January 2018

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Gene-Directed Enzyme Prodrug Therapy

21 January 2018

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Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

21 January 2018

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Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme

21 January 2018

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

21 January 2018

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IUPAC-IUB Commission on Biochemical Nomenclature. A one-letter notation for amino acid sequences. Tentative rules

21 January 2018

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The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.1288

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25 November 2017

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