(Q43633475)

25 November 2017

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Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates (English)

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25 November 2017

1 reference

chemical risk assessment

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inferred from title

object named as

chemical risk assessment

14 July 2023

author name string

Dorne JL

series ordinal

1

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25 November 2017

Walton K

series ordinal

2

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25 November 2017

Renwick AG

series ordinal

3

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25 November 2017

publication date

1 July 2001

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Food and Chemical Toxicology

25 November 2017

published in

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25 November 2017

volume

39

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25 November 2017

issue

7

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25 November 2017

page(s)

681-696

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Theophylline pharmacokinetics and liver function indexes in chronic liver disease

25 November 2017

cites work

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Pharmacokinetic profile of caffeine in the premature newborn infant with apnea

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7 January 2021

Pharmacokinetics of diuretics and methylxanthines in the neonate

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7 January 2021

A comparison of the pharmacokinetics of theophylline in asthmatic children in the acute episode and in remission

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7 January 2021

Theophylline kinetics in chronic obstructive airway disease in the elderly

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7 January 2021

The effect of acute and chronic renal failure on theophylline clearance

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7 January 2021

Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics

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7 January 2021

The absolute bioavailability of caffeine in man

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7 January 2021

Comparative pharmacokinetics of caffeine in young and elderly men

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7 January 2021

Pharmacokinetics of theophylline in young and elderly subjects

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7 January 2021

Addressing human variability in risk assessment--the robustness of the intraspecies uncertainty factor

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7 January 2021

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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7 January 2021

A urinary metabolite ratio that reflects systemic caffeine clearance

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7 January 2021

Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

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7 January 2021

Kinetics of intravenous theophylline

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7 January 2021

Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes

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7 January 2021

Disposition of a flow-limited drug (lidocaine) and a metabolic capacity-limited drug (theophylline) in liver cirrhosis.

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7 January 2021

Onset of xenobiotic metabolism in children: toxicological implications

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7 January 2021

Theophylline kinetics in relation to age: the importance of smoking

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7 January 2021

Dose-dependency of caffeine metabolism with repeated dosing

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7 January 2021

The effect of liver disease on urine caffeine metabolite ratios

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7 January 2021

Impaired elimination of caffeine in cirrhosis

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7 January 2021

Evolution of science-based uncertainty factors in noncancer risk assessment

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7 January 2021

Regulatory history and experimental support of uncertainty (safety) factors

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7 January 2021

Hepatic drug metabolism and aging

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7 January 2021

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

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7 January 2021

Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease

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7 January 2021

Theophylline kinetics in a geriatric group

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7 January 2021

Theophylline pharmacokinetics in pregnancy.

1 reference

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7 January 2021

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

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7 January 2021

Theophylline disposition in obesity

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7 January 2021

Effects of tobacco smoking and oral contraceptive use on theophylline disposition

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7 January 2021

Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism

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7 January 2021

Theophylline pharmacokinetics in premature infants with apnea

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7 January 2021

Factors influencing theophylline disposition in 179 newborns

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7 January 2021

Pharmacokinetic aspects of caffeine in premature infants with apnoea

1 reference

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7 January 2021

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

1 reference

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7 January 2021

Risk evaluation: criteria arising from legal traditions and experience with quantitative risk assessment in the United States

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7 January 2021

Human variability in susceptibility to toxic chemicals--a preliminary analysis of pharmacokinetic data from normal volunteers

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7 January 2021

The mechanism of the interaction between amiodarone and warfarin in humans

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7 January 2021

Bioavailability and pharmacokinetics of theophylline following plain uncoated and sustained-release dosage forms in relation to smoking habit. II. Multiple dose study

1 reference

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7 January 2021

Theophylline pharmacokinetics in black Zimbabwean males

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7 January 2021

Influence of smoking on caffeine elimination in healthy volunteers and in patients with alcoholic liver cirrhosis

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7 January 2021

Influence of race or ethnicity on pharmacokinetics of drugs

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7 January 2021

Predictability of the effects of race or ethnicity on pharmacokinetics of drugs.

1 reference

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7 January 2021

Chronopharmacokinetics of theophylline after sustained release and intravenous administration to adults.

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7 January 2021

Effects of altitude (4300 M) on the pharmacokinetics of caffeine and cardio-green in humans

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7 January 2021

Human P450 metabolism of warfarin

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7 January 2021

Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans

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7 January 2021

The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease

1 reference

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7 January 2021

Effect of hemodialysis on the pharmacokinetics of theophylline in chronic renal failure

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7 January 2021

Alterations in theophylline metabolism during the first year of life

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7 January 2021

Tacrine is not an ideal probe drug for measuring CYP1A2 activity in vivo

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7 January 2021

The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis.

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7 January 2021

Quantitative assessment of caffeine partial clearances in man.

1 reference

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7 January 2021

Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.

1 reference

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7 January 2021

Pharmacokinetic changes during pregnancy and their clinical relevance

1 reference

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7 January 2021

Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in male nonsmokers

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7 January 2021

Pharmacokinetic analysis of the disposition of intravenous theophylline in young children

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7 January 2021

Pharmacokinetics of theophylline in hepatic disease

1 reference

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7 January 2021

Effects of cimetidine on caffeine disposition in smokers and nonsmokers

1 reference

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7 January 2021

Uncertainty and variability in human exposures to soil contaminants through home-grown food: a Monte Carlo assessment

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7 January 2021

The effect of smoking on caffeine elimination: implications for its use as a semiquantitative test of liver function

1 reference

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7 January 2021

Plasma and salivary pharmacokinetics of caffeine in man

1 reference

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7 January 2021

Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population

1 reference

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7 January 2021

Drug metabolism in pregnancy, infancy and childhood

1 reference

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7 January 2021

Theophylline disposition in patients with hepatic cirrhosis

1 reference

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7 January 2021

Maturation of caffeine N-demethylation in infancy: a study using the 13CO2 breath test

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7 January 2021

Safety factors and establishment of acceptable daily intakes

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7 January 2021

Data-derived safety factors for the evaluation of food additives and environmental contaminants

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7 January 2021

Inter-ethnic differences in xenobiotic metabolism

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7 January 2021

Human variability and noncancer risk assessment- An analysis of the default uncertainty factor

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7 January 2021

Toxicokinetics in infants and children in relation to the ADI and TDI.

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7 January 2021

An analysis of the need for an additional uncertainty factor for infants and children

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7 January 2021

Theophylline pharmacokinetics after intramuscular administration.

1 reference

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7 January 2021

Elimination of theobromine metabolites in healthy adults

1 reference

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7 January 2021

Pharmacokinetics of intravenous theophylline in pregnant patients at term

1 reference

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7 January 2021

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1 reference

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7 January 2021

Pharmacokinetics of intravenous caffeine in critically ill patients.

1 reference

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7 January 2021

Caffeine clearance and biotransformation in patients with chronic liver disease

1 reference

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7 January 2021

Theophylline pharmacokinetics in normal elderly subjects

1 reference

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7 January 2021

High levels of methylxanthines in chocolate do not alter theobromine disposition

1 reference

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7 January 2021

Delayed ontogenesis of CYP1A2 in the human liver

1 reference

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7 January 2021

Theobromine kinetics and metabolic disposition

1 reference

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7 January 2021

The effect of vitamin C on the pharmacokinetics of caffeine in elderly men

1 reference

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7 January 2021

The concept of the acceptable daily intake: an historical review

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7 January 2021

Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates

1 reference

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7 January 2021

Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation

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7 January 2021

Relationship between caffeine concentrations in plasma and saliva

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7 January 2021

10.1016/S0278-6915(01)00005-9

Identifiers

DOI

1 reference

25 November 2017

1 reference