(Q43633471)

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Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates

scientific article published in July 2001

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 November 2017

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Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

chemical risk assessment

1 reference

based on heuristic

inferred from title

object named as

chemical risk assessment

14 July 2023

pharmacokinetics

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based on heuristic

inferred from title

author name string

Walton K

1

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Dorne JL

2

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Renwick AG

3

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

publication date

1 July 2001

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Food and Chemical Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

667-680

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene

1 reference

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Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies

1 reference

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7 January 2021

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Caffeine metabolism in the newborn

1 reference

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7 January 2021

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Accelerated clearance of intravenously administered theophylline and phenobarbital by oral doses of activated charcoal in rats. A possibility of the intestinal dialysis

1 reference

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7 January 2021

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Identification, kinetic and quantitative study of [2-14C] and [1-Me-14C]caffeine metabolites in rat's urine by chromatographic separations

1 reference

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7 January 2021

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Metabolic pathway of theobromine in the rat and identification of two new metabolites in human urine

1 reference

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7 January 2021

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Theophylline kinetics: dose dependency and single sample prediction of clearance

1 reference

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7 January 2021

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Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes

1 reference

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7 January 2021

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Comparative pharmacokinetics of caffeine in young and elderly men

1 reference

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7 January 2021

based on heuristic

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Caffeine disposition after oral doses

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetics and metabolism of theobromine in male rats

1 reference

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7 January 2021

based on heuristic

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Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouse

1 reference

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7 January 2021

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Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit

1 reference

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7 January 2021

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Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

1 reference

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7 January 2021

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Pharmacokinetics of theophylline before and after nephrectomy in dogs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Urinary excretion of caffeine and its metabolites in the mouse

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Does the animal-to-human uncertainty factor incorporate interspecies differences in surface area?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of theophylline and its metabolites in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patt

1 reference

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7 January 2021

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Respiratory Acidemia and Theophylline Pharmacokinetics in the Awake Dog

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Caffeine and paraxanthine pharmacokinetics in the rabbit: concentration and product inhibition effects

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

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Regulatory history and experimental support of uncertainty (safety) factors

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Evolution of science-based uncertainty factors in noncancer risk assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

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Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of caffeine by mouse liver microsomes: GSH or cytosol causes a shift in products from 1,3,7-trimethylurate to a substituted diaminouracil

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

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Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Interspecies metabolism and pharmacokinetic scaling of theophylline disposition

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Studies on methyl-xanthines in intact and hypophysectomised rats: differences in pharmacokinetics and adrenocortical response

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship of urinary metabolites of theophylline to serum theophylline levels

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic rate of female rats as a function of age and body size

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Multiplicity of cytochrome P-450 species involved in theophylline metabolism in mouse hepatic microsomes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of amiodarone on theophylline pharmacokinetics in the rat

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Caffeine disposition and effects in young and one-year-old rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetics and metabolism of theobromine in male and female non-pregnant and pregnant rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative assessment of caffeine partial clearances in man.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety assessments of chemicals with thresholded effects.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Acceptable daily intake: Inception, evolution, and application

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Elimination kinetics and protein binding of theophylline in the rabbit

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer

1 reference

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7 January 2021

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inferred from DOI database lookup

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of Tamoxifen on the Pharmacokinetics of Theophylline in Rats

1 reference

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7 January 2021

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Circadian Rhythms in Theophylline Disposition: Simulations and Observations in the Dog

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of two new metabolites of caffeine in the rat urine

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Fluvoxamine is a potent inhibitor of the metabolism of caffeine in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety factors and establishment of acceptable daily intakes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Data-derived safety factors for the evaluation of food additives and environmental contaminants

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human variability and noncancer risk assessment- An analysis of the default uncertainty factor

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Elimination of theobromine metabolites in healthy adults

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of theophylline: a dose-range study

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro metabolism of theophylline by rat and human liver tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation and characterization of four cytochrome P450 isozymes from untreated and phenobarbital-treated beagle dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Theobromine metabolism and pharmacokinetics in pregnant and nonpregnant Sprague-Dawley rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

High levels of methylxanthines in chocolate do not alter theobromine disposition

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Diet-induced alterations in theobromine disposition and toxicity in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Temporal variation in the disposition of theophylline and its metabolites.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in caffeine, lidocaine and trimethadione metabolism in carbon tetrachloride-intoxicated rats as assessed by a "cocktail" study.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Theobromine kinetics and metabolic disposition

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Dose-dependent elimination of theophylline in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The concept of the acceptable daily intake: an historical review

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of Caffeine on Circulating Theophylline Levels in Beagle Dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Extrapolation of animal toxicity to humans: interspecies comparisons in drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of phenobarbital and 3-methylcholanthrene pretreatment on the plasma half-life and urinary excretion profile of theophylline and its metabolites in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative Pharmacokinetics of Theophylline in Rabbits and in Humans with Hyperlipidemia

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetic interactions between isoniazid and theophylline in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2801%2900006-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0278-6915(01)00006-0

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

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