(Q43638841)

English

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

scientific article published on 12 June 2001

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

author name string

Calugaru SV

1

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Swanson R

2

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Olson ST

3

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

language of work or name

0 references

publication date

12 June 2001

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

276

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

35

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

32446-32455

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.

1 reference

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21 January 2018

A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

1 reference

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21 January 2018

The inhibition mechanism of serpins. Evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex.

1 reference

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21 January 2018

An ester bond linking a fragment of a serine proteinase to its serpin inhibitor.

1 reference

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21 January 2018

Properties of antithrombin-thrombin complex formed in the presence and in the absence of heparin

1 reference

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21 January 2018

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

1 reference

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21 January 2018

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

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21 January 2018

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

1 reference

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21 January 2018

Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex

1 reference

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21 January 2018

Structural basis for serpin inhibitor activity

1 reference

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21 January 2018

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

1 reference

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21 January 2018

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

The P6-P2 region of serpins is critical for proteinase inhibition and complex stability

1 reference

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21 January 2018

pH Dependence of chymotrypsin catalysis. Appendix. Substrate binding to dimeric α-chymotrypsin studied by x-ray diffraction and the equilibrium method

1 reference

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21 January 2018

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

1 reference

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21 January 2018

High molecular weight kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin: role for antithrombin in the regulation of kallikrein

1 reference

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21 January 2018

The Size and Shape of Human and Bovine Antithrombin III

1 reference

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21 January 2018

Resolution of α and β anhydrotrypsin by affinity chromatography

1 reference

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21 January 2018

Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a beta-like variant in baculovirus-infected insect cells

1 reference

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21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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21 January 2018

Linkage between proton binding and amidase activity in human alpha-thrombin: effect of ions and temperature

1 reference

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21 January 2018

Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Formation of the covalent chymotrypsin.antichymotrypsin complex involves no large-scale movement of the enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Ligand binding to thrombin exosite II induces dissociation of the thrombin-heparin cofactor II(L444R) complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Structural basis of the activation and action of trypsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A beta-sheet of the inhibitor during trapping of target proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Kinetic characterization of the proteinase binding defect in a reactive site variant of the serpin, antithrombin. Role of the P1' residue in transition-state stabilization of antithrombin-proteinase complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Conformational stability of the covalent complex between elastase and alpha 1-proteinase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Distortion of the active site of chymotrypsin complexed with a serpin

1 reference

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21 January 2018

Change in environment of the P1 side chain upon progression from the Michaelis complex to the covalent serpin-proteinase complex

1 reference

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21 January 2018

The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites

1 reference

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21 January 2018

Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms

1 reference

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21 January 2018

Catalytic properties of serine proteases. 2. Comparison between human urinary kallikrein and human urokinase, bovine beta-trypsin, bovine thrombin, and bovine alpha-chymotrypsin

1 reference

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21 January 2018

Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. Stereochemical interpretation

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21 January 2018

Isolation of human blood coagulation alpha-factor Xa by soybean trypsin inhibitor-sepharose chromatography and its active-site titration with fluorescein mono-p-guanidinobenzoate

1 reference

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21 January 2018

Apparent formation of sodium dodecyl sulfate-stable complexes between serpins and 3,4-dichloroisocoumarin-inactivated proteinases is due to regeneration of active proteinase from the inactivated enzyme

1 reference

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21 January 2018

Reaction of thrombins with human antithrombin III. I. Enzyme activity losses unrelated to the inhibitory reaction and their prevention

1 reference

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21 January 2018

Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104731200

21 January 2018

Catalysis by chymotrypsinogen. Demonstration of an acyl-zymogen intermediate

1 reference

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21 January 2018

Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1

1 reference

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21 January 2018

Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease

1 reference

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21 January 2018

The single calcium‐binding site of crystalline bovine β‐trypsin

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M104731200

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

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