(Q43783930)

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Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time

scientific article published on 28 June 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 November 2017

Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

1 reference

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author name string

Georges Vauquelin

1

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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publication date

28 June 2013

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Europe PubMed Central

PubMed publication ID

26 November 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

PubMed publication ID

26 November 2017

386

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

949-962

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions

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Drug-target residence time: critical information for lead optimization.

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New protein engineering approaches to multivalent and bispecific antibody fragments

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Affinity and avidity in antibody-based tumor targeting

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A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor

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Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterol

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Residence time of receptor-ligand complexes and its effect on biological function

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The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors

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Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time

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21 January 2018

Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

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21 January 2018

Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

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Slow antagonist dissociation and long-lasting in vivo receptor protection

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21 January 2018

Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems

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Model and Simulation of Multivalent Binding to Fixed Ligands

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Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

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The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

1 reference

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Analysis of mass transport-limited binding kinetics in evanescent wave biosensors

1 reference

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12 December 2020

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Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays

1 reference

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Quantifying the rebinding effect in multivalent chemical ligand-receptor systems.

1 reference

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inferred from PubMed ID database lookup

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1 reference

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1 reference

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Identifiers

10.1007/S00210-013-0881-0

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

release_42abhbolcvbtfiztskplp2kvcu

1 reference

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24 November 2022

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1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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