(Q43832782)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

title

Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

author name string

Charles M Marson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

Alphonso S Rioja

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

R Charles Coombes

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

David M Vigushin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

language of work or name

English

0 references

publication date

1 January 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry Letters

5 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

volume

12

1 reference

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5 December 2019

issue

2

1 reference

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5 December 2019

page(s)

255-259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11755366%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy

5 December 2019

cites work

1 reference

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7 January 2021

Ras farnesyltransferase: a new therapeutic target

1 reference

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7 January 2021

Ras C-terminal processing enzymes--new drug targets?

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7 January 2021

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7 January 2021

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

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7 January 2021

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

1 reference

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7 January 2021

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

1 reference

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7 January 2021

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

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7 January 2021

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

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7 January 2021

Protein prenylation: molecular mechanisms and functional consequences

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7 January 2021

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

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7 January 2021

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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7 January 2021

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

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7 January 2021

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

1 reference

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7 January 2021

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

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7 January 2021

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

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7 January 2021

Terpenoid Chemistry. IV. The Turpentine of Araucaria cunninghamii Ait

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7 January 2021

Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes).

1 reference

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7 January 2021

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

1 reference

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7 January 2021

Synthesis of Protein Farnesyltransferase and Protein Geranylgeranyltransferase Inhibitors: Rapid Access to Chaetomellic Acid A and Its Analogues

1 reference

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7 January 2021