(Q43861174)

27 November 2017

title

Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma (English)

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27 November 2017

Yuriko Minegishi

1

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27 November 2017

Daisuke Iejima

2

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27 November 2017

Hiroaki Kobayashi

3

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27 November 2017

Zai-Long Chi

4

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27 November 2017

Kazuhide Kawase

5

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27 November 2017

Tetsuya Yamamoto

6

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27 November 2017

Tomohisa Seki

7

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27 November 2017

Shinsuke Yuasa

8

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27 November 2017

Keiichi Fukuda

9

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27 November 2017

Takeshi Iwata

10

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27 November 2017

publication date

12 May 2013

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27 November 2017

published in

Human Molecular Genetics

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27 November 2017

volume

22

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27 November 2017

issue

17

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27 November 2017

page(s)

3559-3567

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The number of people with glaucoma worldwide in 2010 and 2020

27 November 2017

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Confirmation of TBK1 duplication in normal tension glaucoma

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Adult-onset primary open-angle glaucoma caused by mutations in optineurin

21 January 2018

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Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

21 January 2018

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Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.

21 January 2018

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Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types

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Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

21 January 2018

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Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway

21 January 2018

1 reference

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Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

21 January 2018

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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

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21 January 2018

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Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States

21 January 2018

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Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

21 January 2018

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Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Optineurin in primary open angle glaucoma

21 January 2018

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Processing of optineurin in neuronal cells

21 January 2018

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Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

21 January 2018

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Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

21 January 2018

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Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

21 January 2018

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Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins

21 January 2018

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Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein

21 January 2018

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Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

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A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

21 January 2018

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Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma.

21 January 2018

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT210

21 January 2018

Identifiers

DOI

10.1093/HMG/DDT210

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27 November 2017

1 reference