(Q39869345)

English

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

scientific article published on 22 March 2009

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scholarly article

1 reference

Europe PubMed Central

15 September 2017

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation (English)

1 reference

Europe PubMed Central

15 September 2017

1 reference

based on heuristic

inferred from title

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Kristopher Clark

1

1 reference

Europe PubMed Central

15 September 2017

Lorna Plater

2

1 reference

Europe PubMed Central

15 September 2017

Mark Peggie

3

1 reference

Europe PubMed Central

15 September 2017

Philip Cohen

4

1 reference

Europe PubMed Central

15 September 2017

language of work or name

0 references

publication date

22 March 2009

1 reference

Europe PubMed Central

15 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

15 September 2017

284

1 reference

Europe PubMed Central

15 September 2017

14136-14146

1 reference

Europe PubMed Central

15 September 2017

21

1 reference

Europe PubMed Central

15 September 2017

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

1 reference

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22 September 2017

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation

1 reference

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22 September 2017

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

1 reference

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22 September 2017

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

1 reference

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22 September 2017

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

1 reference

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22 September 2017

MDA5/RIG-I and virus recognition.

1 reference

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22 September 2017

Shared principles in NF-kappaB signaling

1 reference

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22 September 2017

The selectivity of protein kinase inhibitors: a further update

1 reference

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22 September 2017

Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release

1 reference

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22 September 2017

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

1 reference

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22 September 2017

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

1 reference

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22 September 2017

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

1 reference

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22 September 2017

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway

1 reference

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22 September 2017

Pathogen recognition and innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Innate immune recognition of viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

TRPM7, a novel regulator of actomyosin contractility and cell adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

1 reference

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22 September 2017

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

1 reference

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22 September 2017

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

IkappaB kinase is an essential component of the Tpl2 signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

1 reference

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IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2

1 reference

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22 September 2017

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

1 reference

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22 September 2017

NAK is an IkappaB kinase-activating kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

22 September 2017

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1 reference

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22 September 2017

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

1 reference

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22 September 2017

Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation

1 reference

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22 September 2017

Phosphorylation and activation of p70s6k by PDK1

1 reference

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22 September 2017

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

1 reference

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20 August 2018

Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

20 August 2018

Essential function for the kinase TAK1 in innate and adaptive immune responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682862

20 August 2018

Identifiers

10.1074/JBC.M109.000414

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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