(Q44085156)

English

The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.

scientific article published in August 2002

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scholarly article

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11 November 2019

The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons (English)

1 reference

Europe PubMed Central

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11 November 2019

Andrew John Lees

7

object named as

Andrew J Lees

2 references

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29 November 2017

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11 November 2019

author name string

Michelle A Utton

1

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11 November 2019

James Connell

2

1 reference

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11 November 2019

Ayodeji A Asuni

3

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11 November 2019

Marjon van Slegtenhorst

4

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11 November 2019

Michael Hutton

5

1 reference

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11 November 2019

Rohan de Silva

6

1 reference

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11 November 2019

Chris C J Miller

8

1 reference

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11 November 2019

Brian H Anderton

9

1 reference

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11 November 2019

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publication date

1 August 2002

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11 November 2019

Journal of Neuroscience

1 reference

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11 November 2019

22

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11 November 2019

6394-6400

1 reference

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11 November 2019

15

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11 November 2019

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal polarity: controlling the sorting and diffusion of membrane components

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of selective transport in neuronal protein sorting

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate slows axonal transport of neurofilaments in transfected neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular genetics of the tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional differences of tau isoforms containing 3 or 4 C-terminal repeat regions and the influence of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal transport of tubulin and actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of tau protein in non-neuronal cells: microtubule binding and stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow axonal transport: the polymer transport model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow axonal transport: the subunit transport model

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein binds to microtubules through a flexible array of distributed weak sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal transport of a subclass of tau proteins: evidence for the regional differentiation of microtubules in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of microtubule-associated proteins and brain development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilament monoclonal antibodies RT97 and 8D8 recognize different modified epitopes in paired helical filament-tau in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tau protein regions required for process formation in PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domains of tau protein and interactions with microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau is enriched on dynamic microtubules in the distal region of growing axons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential axonal transport of soluble and insoluble tau in the rat sciatic nerve.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The slow axonal transport of cytoskeletal proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motile properties of vimentin intermediate filament networks in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau mutations cause frontotemporal dementias.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

1 reference

https://pubmed.ncbi.nlm.nih.gov/12151518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-15-06394.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12151518%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12151518%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12151518%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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