(Q44143302)

30 November 2017

title

The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines (English)

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30 November 2017

David C Swinney

1

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30 November 2017

publication date

27 August 2013

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Journal of Biomolecular Screening

30 November 2017

published in

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30 November 2017

volume

18

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30 November 2017

issue

10

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30 November 2017

page(s)

1186-1192

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How were new medicines discovered?

30 November 2017

cites work

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https://api.crossref.org/works/10.1177%2F1087057113501199

Phenotypic vs. target-based drug discovery for first-in-class medicines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

ucb L059, a novel anti-convulsant drug: pharmacological profile in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

N-acylphenylalanines and related compounds. A new class of oral hypoglycemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Ranolazine, a novel agent for chronic stable angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Development of daptomycin for gram-positive infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Misconceptions about calcimimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Omacetaxine as an anticancer therapeutic: what is old is new again

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Revisiting AMPA receptors as an antiepileptic drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

A personal perspective on Dr. Paul Janssen

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Identifying mechanism-of-action targets for drugs and probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113501199

21 January 2018

Identifiers

DOI

10.1177/1087057113501199

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30 November 2017

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